目的 研究聯(lián)合使用復(fù)方甘草酸苷片和生長(zhǎng)因子凝膠治療面部激素依賴性皮炎的臨床療效。方法 選取延安大學(xué)咸陽(yáng)醫(yī)院收治的面部激素依賴性皮炎患者共148例,隨機(jī)分為對(duì)照組和觀察組,每組各74例。其中對(duì)照組單獨(dú)使用復(fù)方甘草酸苷片治療;觀察組聯(lián)合使用復(fù)方甘草酸苷片和生長(zhǎng)因子凝膠。兩組均持續(xù)進(jìn)行4周的治療,每周測(cè)量患者皮損面積,記錄患者治療前后皮損面積和瘙癢程度的變化,并評(píng)價(jià)最終臨床療效。結(jié)果 經(jīng)過(guò)治療后,觀察組和對(duì)照組均可以顯著降低皮損面積,與治療前比較差異顯著(P<0.05、0.01)。經(jīng)過(guò)治療后,患者臨床癥狀積分和瘙癢評(píng)分均顯著降低(P<0.01),且觀察組患者皮損面積、臨床癥狀積分、瘙癢評(píng)分均顯著低于對(duì)照組(P<0.05)。經(jīng)過(guò)治療后,觀察組的總有效率顯著優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 聯(lián)合使用復(fù)方甘草酸苷片和生長(zhǎng)因子凝膠效果顯著,可以在臨床推廣使用。

Objective To investigate the clinical analysis on Compound Glycyrrhizin Tablets (CGT) combined with Growth Factor Gel (GFG) in treatment of hormone dependent dermatitis. Methods Patients (148 cases) with hormone dependent dermatitis in Xianyang Hospital, were randomly divided into the observation group and control group. The patients of observation group were given CGT combined with GFG, while the control group were given CGT. The treatment were for 4 weeks, the patients with skin lesion area were measured every weeks, the skin lesion clinical observation indexes before and after treatments were recorded, and the final itching grade and final clinical efficacy evaluation results were recorded. Results The observation and control group could obviously decrease skin lesion after treatment (P<0.05, 0.01), the skin lesion area and skin lesion clinical observation indexes were significant lower than those in the control group (P<0.05), the itching grade of observation group was obvious lower than that of the control group (P<0.05), the total efficacy of observation group was higher than that of the control group (P<0.05). Conclusion The efficacy of CGT combined with GFG was significant, which could be worth of promotion, and has certain improved space.