動(dòng)物實(shí)驗(yàn)證實(shí)熊果酸和齊墩果酸對(duì)多種原因的腎損傷及移植腎都有保護(hù)作用,包括藥物(如馬兜鈴酸、阿霉素、慶大霉素、四氯化碳、環(huán)孢菌素等引起的)、高血糖、高血壓、梗阻和缺血再灌注引起的腎損傷。熊果酸和齊墩果酸對(duì)正常和腎臟受損動(dòng)物都有促進(jìn)尿鈉排出,提高腎小球?yàn)V過(guò)率和肌酐清除率的作用。熊果酸能抑制多種前列腺癌細(xì)胞和膀胱癌細(xì)胞增殖并誘導(dǎo)其凋亡;整體實(shí)驗(yàn)證實(shí)其可抑制小鼠前列腺癌發(fā)生和發(fā)展,防止睪酮引起大鼠良性前列腺增生;在較低濃度時(shí)能阻滯大腸埃希桿菌與尿路上皮細(xì)胞黏附,有望防止尿路感染發(fā)生。齊墩果酸可抑制尿鈣排出和阻滯尿石形成。

It has been proved that ursolic and oleanolic acids possess nephroprotective effects against drug(ie aristolochic acid, adriamycin, gentamycin, carbon tetrachloride or cyclosporine)-, hyperglycemia-, hypertension-, obstruction-, ischemia-reperfusion- induced renal injury and grafting kidney by animal experiments. Ursolic and oleanolic acids have the improving actions on natriuresis, glomerular filtration rate and creatinine clearance in normal and kidney-injured animals. Ursolic acid inhibits proliferation against various prostate cancer cells and bladder cancer cells, and induced apoptosis. It has been proved by animal experiments in vivo that ursolic acid inhibits the initiation and progression of prostate cancer in mice, and testosterone-induced benign prostatic hyperplasia in rats. Ursolic acid at lower concentration can reduce the adhesion of uropathogenic Escherichia coli strains to uroepithelial cells, and prevent from urinary tract infections. Oleanolic acid can reduce the urinary calcium output, and prevent from urolithiasis.