目的 研究蟲草素制劑對百草枯致大鼠肺纖維化的治療作用。方法 90只健康雄性SD大鼠隨機分為：對照組、模型組，地塞米松（陽性藥，1 mg/kg）組，蟲草素制劑低、中、高劑量（125、250、500 mg/kg）組，蟲草活力素A（500 mg/kg）組，蟲草活力素B（500 mg/kg）組。除對照組外，其余各組于實驗第1天ip百草枯溶液17 mg/kg，1次染毒，并開始給藥30 d，期間稱量動物體質(zhì)量，記錄動物大體狀況及死亡情況。給藥結(jié)束，取肺觀察動物肺臟大體情況，檢測肺組織中羥脯氨酸（HYP）水平，并進(jìn)行Masson染色觀察肺纖維化病理變化。結(jié)果 蟲草素制劑可改善肺纖維化大鼠狀態(tài)，促進(jìn)大鼠體質(zhì)量恢復(fù)；蟲草素制劑各個劑量組均能降低肺組織中HYP水平，其中高劑量組、蟲草活力素A和B組與模型組比較差異顯著（P<0.01）；地塞米松組和蟲草素制劑高劑量組以及蟲草活力素A、B組均不同程度的減少了纖維化組織，與模型組比較，纖維化程度較輕。結(jié)論 蟲草素制劑能有效降低肺纖維化大鼠肺組織中HYP水平，改善肺的組織結(jié)構(gòu)和纖維化病理變化。

Objective To study the therapeutic effect of cordycepin preparation on gramoxone-induced pulmonary fibrosis in rats. Methods Totally 90 Wistar rats were divided into eight groups: control group; model group; dexamethasone (positive drug, 1 mg/kg) group; cordycepin preparation low, medium, and high dose groups (125, 250, 500 mg/kg); Cordy Max A (500 mg/kg) group, and CordyMax B (500 mg/kg) group. Pulmonary fibrosis was induced by ip injection of gramoxone (17 mg/kg). Then the rats were treated for 30 d and the body weight, generan situation, and death of the animals were recored. After treatment, lung tissues were examined for hydroxyproline (HYP) levels and lung pathological changes. Results Cordycepin preparation could improve the status of the rats with pulmonary fibrosis induced by bleomycin; All the three doses of cordycepin preparation could reduce animal HYP content in lung tissue, the high dose group and CordyMax A or CordyMax B group compared with the model group were significantly different (P<0.01); Compared with model group, the degree of fibrosis of prednisone acetate group, cordycepin preparation high dose group, CordyMax A and CordyMax B group eased a little. Conclusion Cordycepin preparation can effectively reduce the HYP content in lung tissue of the rats with pulmonary fibrosis induced by gramoxone, improve the organization structure and the pathological changes of lung.