目的 研究金絲桃苷（Hyp）對(duì)急性炎癥疼痛模型小鼠的抗炎鎮(zhèn)痛作用。方法 昆明種小鼠隨機(jī)分為對(duì)照組，Hyp低、中、高劑量（50、100、200 mg/kg）組及氫化可的松（陽性藥，20 mg/kg）組，sc給藥，每天給藥1次，連續(xù)給藥5 d后，建立二甲苯所致小鼠耳廓腫脹和醋酸所致小鼠腹腔毛細(xì)血管通透性增高的急性炎癥模型，觀察Hyp對(duì)小鼠急性炎癥的抗炎作用；陽性藥設(shè)置為嗎啡（1 mg/kg），其余分組及給藥方式同急性炎癥實(shí)驗(yàn)，連續(xù)給藥5 d后，建立小鼠醋酸扭體法和熱甩尾法模型，觀察Hyp對(duì)急性疼痛的鎮(zhèn)痛作用。結(jié)果 100、200 mg/kg的Hyp能夠抑制二甲苯所致小鼠耳廓腫脹、降低急性炎癥引起的毛細(xì)血管通透性增高、減少醋酸扭體次數(shù)、提高小鼠熱刺激痛閾值，與對(duì)照組比較差異顯著（P<0.05、0.01）。結(jié)論 Hyp對(duì)小鼠急性炎癥疼痛具有抑制作用。

Objective To investigate the anti-inflammatory and analgesic effects of hyperin (Hyp) in mice with acute inflammatory pain. Methods Kunming mice were randomly divided into five groups: control group, Hyp low, medium and high dose (50, 100, and 200 mg/kg) groups, and hydrocortisone (positive drug, 20 mg/kg) group, sc relative drug once daily for 5 d. The anti-inflammatory actions of Hyp were tested by evaluating auricle edema levels induced by xylene and blood capillary leakage of abdominal cavity in mice. The positive drug was set to morphine (1 mg/kg), drug administration of other groups was the same as acute inflammation test. After 5 d, acetic acid writhing and thermal tail-flick tests were used to measure the acute analgesic effects. Results Both 100 and 200 mg/kg Hyp inhibited auricle edema levels, reduced blood capillary leakage, decreased the number of writhing, and increased the pain threshold of thermal stimulation. Conclusion Hyp has inhibitory effects in mice with acute inflammatory pain.

國家自然科學(xué)基金面上項(xiàng)目（3077263）