目的 研究30 d重復(fù)皮膚涂抹利多卡因凝膠對(duì)豚鼠產(chǎn)生的毒性反應(yīng)。方法 利多卡因凝膠高、中、低劑量（40、20、10 g/kg）連續(xù)皮膚涂抹給藥30 d，整個(gè)試驗(yàn)期間觀察動(dòng)物的臨床癥狀，測(cè)定體質(zhì)量和攝食量，分別于給藥30 d及停藥后14 d取部分豚鼠進(jìn)行血液學(xué)、血清生化學(xué)、臟器系數(shù)和病理組織學(xué)檢查。結(jié)果 豚鼠未出現(xiàn)因給藥而引起的異常癥狀，各給藥組豚鼠體質(zhì)量增長(zhǎng)和攝食正常；利多卡因凝膠在10、20 g/kg劑量下，豚鼠血液學(xué)、血清生化學(xué)、臟器系數(shù)和病理組織學(xué)等均未見毒理學(xué)意義的異常改變；40 g/kg利多卡因凝膠導(dǎo)致豚鼠血清K⁺水平，腎上腺質(zhì)量及系數(shù)明顯增高（P<0.05），但臟器未出現(xiàn)毒性病理改變；停藥14 d后，上述異常指標(biāo)恢復(fù)正常，也未見其他延遲毒性。結(jié)論 在本試驗(yàn)條件下，皮膚涂抹利多卡因凝膠對(duì)豚鼠無明顯毒性，無毒反應(yīng)劑量為20 g/kg。

Objective To observe the toxic reaction of lidocaine gel on guinea pig by long-term drug toxicity. Methods Daily dermal administration of lidocaine gel at 40, 20, and 10 g/kg for 30 d was used for high, medium, and low dose groups, respectively. Clinical observation, examination of body weight, and feed consumption were performed during whole experimental stage, and then, the hematology, blood-biochemics, organ coefficient, and pathohistology were examined in the end administration period and recovery period, respectively. Results No abnormity was found in all guinea pigs in terms of appearance, behavior, body weight and food consumption. Lidocaine gel has no toxicological abnormal changes of hematology, blood-biochemics, and pathohistology during end administration and convalescent periods at dose of 20 and 10 g/kg. Lidocaine gel of 40 g/kg significantly enhanced the levels of K⁺, and adrenal gland weight and coefficient in end administration period (P<0.05), but toxicological abnormal change of pathohistology was not found, then above changed index regained normal and no other flaccid toxicity also was found in recovery period. Conclusion In the situation of this experiment, repeated dermal administration of lidocaine gel dose not lead to significant toxicity, and 20 g/kg of lidocaine gel is the non-toxic reaction dosage.