目的 探討纈沙坦分散片聯(lián)合前列地爾注射液治療糖尿病腎病的療效。方法 選取延安市人民醫(yī)院腎臟內(nèi)科2012年3月-2015年12月收治的糖尿病腎病230例，隨機(jī)分為兩組。纈沙坦組（109例）口服纈沙坦分散片治療，聯(lián)合用藥組（121例）口服纈沙坦分散片加靜脈滴注前列地爾注射液治療，觀察并記錄治療前后尿素氮（BUN）、血肌酐（Cr）、尿白蛋白排泄率（UAER）、血漿黏度、紅細(xì)胞比容、血沉方程K值、血漿纖維蛋白原等指標(biāo)的變化，評(píng)價(jià)前列地爾注射液聯(lián)合纈沙坦分散片治療糖尿病腎病的療效。結(jié)果 與治療前相比，治療后兩組BUN、Cr、UAER等各項(xiàng)指標(biāo)均明顯下降（P<0.05），且聯(lián)合用藥組這些指標(biāo)明顯低于纈沙坦組（P<0.05）。與治療前相比，治療后兩組血漿黏度、紅細(xì)胞比容、血沉方程K值、血漿纖維蛋白原水平均明顯下降（P<0.05），且聯(lián)合用藥組在上述指標(biāo)的水平均明顯低于纈沙坦組（P<0.05）。隨訪1個(gè)月期間，纈沙坦組不良反應(yīng)6例，聯(lián)合用藥組3例，兩組均無嚴(yán)重不良反應(yīng)。結(jié)論 前列地爾注射液聯(lián)合纈沙坦分散片對(duì)糖尿病腎病具有較好的治療效果，能減少尿蛋白排出，改善腎功能和腎臟血液流變學(xué)指標(biāo)，不良反應(yīng)輕微，值得臨床推廣使用。

Objective To analyze the efficacy of Valsartan Tablets combined with Alprostadil Injection in the treatment of diabetic nephropathy. Methods Totally 230 cases of diabetic nephropathy were selected in Yan'an People's Hospital from March 2012 to December 2015, randomly divided into two groups. The Valsartan group (109 cases) were given Valsartan Tablets. The combination group (121 cases) were given Valsartan Tablets and Alprostadil Injection. The efficacy of the Valsartan Tablets and Alprostadil Injection in the treatment of diabetic nephropathy was evaluated by BUN, Cr, UAER, plasma viscosity, hematocrit, ESR equation K value, and plasma fibrinogen. Results Compared with the values before treatment, the indexes of BUN, Cr, and UAER in two groups were significantly decreased (P<0.05), and the combination group of renal function, and urinary protein index was significantly lower than the Valsartan group (P<0.05). Compared with the values before treatment, the indexes of plasma viscosity, hematocrit, ESR equation K value, and plasma fibrinogen in two groups were significantly decreased (P<0.05). During the 1 month follow-up, there were six cases of adverse reactions in Valsartan group, three cases in the combined treatment group, and no serious adverse reaction in the two groups. Conclusion The Valsartan Tablets combined with Alprostadil Injection had good effect on diabetic nephropathy. This treatment could decrease the urine protein, improve the renal function and hemorheology indexes of kidney and have mild side reaction. It was worthy of clinical application.