[關(guān)鍵詞]
[摘要]
目的 系統(tǒng)評(píng)價(jià)噻奈普汀與阿米替林治療抑郁癥的療效與安全性。方法 檢索從建庫至2016年3月,中國期刊全文數(shù)據(jù)庫(CNKI)、萬方數(shù)據(jù)庫、中文科技期刊全文數(shù)據(jù)庫(VIP)、Cochrane library、PubMed/Medline等數(shù)據(jù)庫中噻奈普汀與阿米替林治療抑郁癥的隨機(jī)對(duì)照試驗(yàn)(RCTs),采用RevMan 5.0軟件對(duì)各效應(yīng)指標(biāo)進(jìn)行Meta分析。結(jié)果 共納入6篇RCTs,714例患者,其中噻奈普汀組(治療組)359例,阿米替林組(對(duì)照組)355例;Meta分析結(jié)果顯示噻奈普汀組與阿米替林組顯效率差異無顯著性[OR=1.56,95% CI(0.87~2.79),P=0.13];兩組頭暈、口干、惡心嘔吐、煩渴、便秘、震顫、排尿困難等不良反應(yīng)差異有顯著性(P<0.05),95% CI上下限均小于1,提示噻奈普汀組在上述不良反應(yīng)發(fā)生率方面小于阿米替林組;其他不良反應(yīng)無顯著性差異。結(jié)論 噻奈普汀與阿米替林治療抑郁癥療效相當(dāng),但噻奈普汀不良反應(yīng)較輕微;該結(jié)論尚需高質(zhì)量、嚴(yán)格設(shè)計(jì)的RCTs進(jìn)一步證實(shí)。
[Key word]
[Abstract]
Objective To evaluate the therapeutic effect and safety of tianeptine and amitriptyline in treatment of depression. Methods Retrieving from created datebase to March 2016 in Cochrane Library, PubMed/Medline, Chinese Journal Full-text Database (CNKI), Wanfang Database, and Chinese Science and Technology Journal Full-text Database (VIP) published on tianeptine and amitriptyline in the treatment of depression of randomized controlled trials(RCTs). Meta-analysis was carried out using RevMan 5.0 software to each effect index. Results A total of six articles were included in the RCTs, 714 patients, including tianeptine (treatment) group 359 cases and amitriptyline (control) group 355 cases. Meta-analysis results showed that there was no statistical significance in clinical efficacy between tianeptine and amitriptyline [OR=1.56, 95% CI (0.87-2.79), P=0.13]. In the incidence of adverse reactions, two groups had dizziness, dry mouth, nausea and vomiting, thirst, constipation, tremor symptoms, and there was significant difference of dysuria(P<0.05), 95% CI was less than 1, rhombus pattern was invalid in the left side of the line, suggesting that tianeptine group in the adverse reaction incidence rate was less than amitriptyline group, another no significant. Conclusion Tianeptine is as effective as amitriptyline for treatment of depression, but the adverse reaction of tianeptine is milder. However, high quality and large-scale RCTs are required for further study.
[中圖分類號(hào)]
[基金項(xiàng)目]
重慶市社會(huì)事業(yè)與民生保障科技創(chuàng)新專項(xiàng)(cstc2015shmszx120073);重慶市萬州區(qū)科技計(jì)劃基金資助項(xiàng)目(201403055)