目的 研究連續(xù)ig給予活絡(luò)效靈丹顆粒對(duì)SD大鼠產(chǎn)生的毒性反應(yīng)。方法 活絡(luò)效靈丹顆粒高、中、低劑量（以生藥計(jì)22.75、16.25、9.75 g/kg）連續(xù)ig給藥26周，整個(gè)實(shí)驗(yàn)期間觀察大鼠的一般狀態(tài)，測(cè)定體質(zhì)量和攝食量，分別于給藥13、26周及停藥恢復(fù)4周取部分大鼠進(jìn)行血液學(xué)指標(biāo)、血清生化學(xué)指標(biāo)、臟器系數(shù)和組織病理學(xué)檢查。結(jié)果 臨床癥狀觀察未見(jiàn)因給藥引起的全身毒性反應(yīng)，但高、中劑量組大鼠在給藥中后期體質(zhì)量增長(zhǎng)緩慢，高劑量組大鼠在給藥初期攝食量下降；血液學(xué)檢查中，活絡(luò)效靈丹顆粒可使血小板（PLT）水平、凝血酶原時(shí)間（PT）和活化部分凝血活酶時(shí)間（APTT）增高，紅細(xì)胞分布寬度（RDW）降低，原因與該藥活血化瘀作用有關(guān)；血清生化學(xué)檢查中，活絡(luò)效靈丹顆粒可降低天冬氨酸氨基轉(zhuǎn)移酶（AST）水平，增加血糖（GLU）、總膽紅素（TBIL）、堿性磷酸酶（ALP）和總膽固醇（CHO）水平；活絡(luò)效靈丹顆粒可使肝臟、腎臟和腎上腺系數(shù)增高；停藥后上述指標(biāo)均可恢復(fù)至正常范圍；組織病理學(xué)檢查未見(jiàn)明顯病變。結(jié)論 活絡(luò)效靈丹顆粒（9.75~22.75 g生藥/kg）對(duì)大鼠長(zhǎng)期給藥，未見(jiàn)明顯毒性反應(yīng)。

Objective To investigate the long-term toxicity reaction of Huoluo Xiaoling Dan Granule (HLXLD) in SD rats. Methods Rats were randomly divided into four groups:control group; HLXLD low, medium, and high dose (dry herbs:22.75, 16.25, and 9.75 g/kg) groups, and HLXLD was orally given for 26 weeks. Clinical observation and examination of body weight and food intake were performed during whole experimental stage. The hematology, blood-biochemics, organ coefficient, and pathohistology were also examined at 13 weeks and 26 weeks during the administration, and at 4 weeks after the withdrawal, respectively. Results No abnormity was found in all rats in clinical observation, but body weight growth of HLXLD medium and high dose groups was retarded during the mid-and late-stage of administration and the amount of food intake of high dose group decreased at the beginning of the administration. In hematology analysis, HLXLD significantly increased platelet (PLT), prothrombin time (PT), and activated partial thromboplastin time (APTT) and significantly decreased red cell distribution width (RDW), which should be associated with the promoting blood circulation and removing blood stasis effect of HLXLD. In biochemistry analysis, HLXLD significantly decreased aspartate aminotransferase (AST), increased blood glucose (GLU), total bilirubin (TBIL), alkaline phosphatase (ALP), and total cholesterol (CHO) contents. In addition, HLXLD elevated the coefficient of liver, kidney, and adrenal gland. In histopathological observation, HLXLD showed no apparent influence in organs of rats. No delayed toxicity reaction was showed at four weeks after the administration. Conclusion HLXLD (9.75 to 22.75 g/kg) shows no obvious toxicity in rats for long-term administration.