目的 觀察纈沙坦聯(lián)合賴諾普利應(yīng)用于原發(fā)性高血壓患者治療對(duì)其血脂和腎功能的影響。方法 選擇攀枝花市中心醫(yī)院于2014年1月-2015年3月收治的原發(fā)性高血壓患者85例作為研究對(duì)象，按照配對(duì)分組法分為兩組，對(duì)照組40例，給予賴諾普利治療，觀察組45例，給予纈沙坦聯(lián)合賴諾普利治療，均連續(xù)治療12周，比較兩組患者療效，并測(cè)定兩組患者血脂及腎功能進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果 觀察組總有效率為91.1%，顯著高于對(duì)照組67.5%（P<0.05）。治療12周后，觀察組總膽固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）水平均顯著低于對(duì)照組（P<0.05），高密度脂蛋白（HDL-C）水平顯著高于對(duì)照組（P<0.05）。觀察組肌酐（Cr）、血尿素氮（BUN）水平均低于對(duì)照組（P<0.05）。結(jié)論 纈沙坦聯(lián)合賴諾普利治療原發(fā)性高血壓患者療效較佳，具有較強(qiáng)調(diào)脂作用，并可延緩高血壓所致的腎功能損害，具有重要臨床價(jià)值。

Objective To observe the influence of Valsartan and Lisinopril on blood lipid and renal function in patients with primary hypertension. Methods Patients (85 cases) with primary hypertension treated in Panzhihua Central Hospital in January 2014 to March 2015 were selected as research objects, then according to the paired grouping method all patients were divided into two groups. There were 40 cases in control group who were given Lisinopril treatment; 45 cases in observation group treated with combination of Valsartan and Lisinopril. Both groups were treated for 12 weeks. The efficacies of two groups were compared and blood lipid and renal function were determined and statistically analyzed. Results The total effective rate of the observation group was 91.1% and significantly higher than control group of 67.5% (P<0.05). After 12 weeks treatment, the levels of TG, LDL-C, and TC in the observation group were significantly lower than those in the control group (P<0.05), and the level of HDL-C was significantly higher than that in the control group (P<0.05). The levels of BUN and Cr in the observation group were lower than those in the control group (P<0.05). Conclusion The clinical effect of Valsartan combined with Lisinopril in primary hypertension patients is better, and it has stronger lipid regulating function and could delay impairing renal function caused by hypertension, so it has more clinical value.