目的 研究奧曲肽與泮托拉唑單獨(dú)與聯(lián)合治療非靜脈曲張性上消化道出血的有效性及安全性。方法 選擇2013年1月~2015年12月在延安大學(xué)附屬醫(yī)院進(jìn)行診治的非靜脈曲張性上消化道出血患者162例，隨機(jī)分為3組，每組54例。奧曲肽組給予奧曲肽單獨(dú)治療，泮托拉唑組給予泮托拉唑單獨(dú)治療，聯(lián)合組給予奧曲肽與泮托拉唑聯(lián)合治療。比較3組的療效、失血量、出血時(shí)間、血紅蛋白水平和胃管引流液pH值。結(jié)果 聯(lián)合組的有效率為94.44%，明顯高于奧曲肽組的75.93%和泮托拉唑組的77.78%（P<0.05）；聯(lián)合組的失血量和止血時(shí)間均明顯低于奧曲肽組和泮托拉唑組（P<0.05），治療后3組的血紅蛋白水平均明顯升高（P<0.05），且聯(lián)合組明顯高于奧曲肽組和泮托拉唑組（P<0.05）；治療后3組的胃管引流液pH值均明顯升高（P<0.05），且聯(lián)合組明顯高于奧曲肽組和泮托拉唑組（P<0.05）。結(jié)論 奧曲肽與泮托拉唑聯(lián)合治療非靜脈曲張性上消化道出血的療效明顯由于單獨(dú)治療，安全有效，值得應(yīng)用推廣。

Objective To investigate the efficacy and safety of octreotide and pantoprazole alone and combined treatment on patients with nonvariceal upper gastrointestinal bleeding. Methods Patients with nonvariceal upper gastrointestinal bleeding (162 cases) treated in Yan'an University Affiliated Hospital from January 2013 to December 2015 were selected and divided into three groups randomly. The patients in octreotide group were given octreotide therapy alone, the patients in pantoprazole group were given pantoprazole therapy alone, and the patients in combination group were given octreotide and pantoprazole combination therapy. The curative effect, blood loss, bleeding time, hemoglobin level, and stomach tube drainage liquid pH value of three groups were compared. Results The effective rate of combination group was 94.44%, significantly higher than octreotide group and pantoprazole group (P<0.05); The blood loss and bleeding time of combinartion group were significantly lower than octreotide group and pantoprazole group (P<0.05). After treatment, the hemoglobin levels in three groups were significantly increased (P<0.05), and the combinartion group was significantly higher than octreotide group and pantoprazole group (P<0.05). After treatment, stomach tube drainage liquid pH value was significantly increased (P<0.05), and the combinartion group was significantly higher than octreotide group and pantoprazole group (P<0.05). Conclusion Octreotide and pantoprazole combined treatment has good efficacy and safety for patients with nonvariceal upper gastrointestinal bleeding, which is worthy of application.