目的 比較佐匹克隆與艾司唑侖治療老年睡眠障礙的臨床療效。方法 選取陜西省人民醫(yī)院收治的200例老年睡眠障礙患者，隨機(jī)分為兩組，艾司唑侖組（96例）給予艾司唑侖治療，佐匹克隆組（104例）采用佐匹克隆治療，通過(guò)對(duì)患者治療2周的療效，治療前、治療2周的SRSS評(píng)分、HAMA評(píng)分及不良反應(yīng)情況進(jìn)行記錄，評(píng)價(jià)佐匹克隆與艾司唑侖治療老年睡眠障礙的療效。結(jié)果 治療2周，佐匹克隆組與艾司唑侖組治療睡眠障礙的有效率分別為95.2%和90.6%，兩組有效率相比，差異沒(méi)有統(tǒng)計(jì)學(xué)意義。與治療前相比，治療2周，兩組SRSS評(píng)分均明顯降低（P<0.05），但兩組間SRSS評(píng)分相比，差異沒(méi)有統(tǒng)計(jì)學(xué)意義。與治療前相比，治療2周兩組HAMA評(píng)分均有所降低（P<0.05），但佐匹克隆組HAMA評(píng)分與艾司唑侖組相比，差異沒(méi)有統(tǒng)計(jì)學(xué)意義。治療2周期間，佐匹克隆組不良反應(yīng)發(fā)生率明顯低于艾司唑侖組（P<0.05）。結(jié)論 艾司唑侖和佐匹克隆對(duì)老年睡眠障礙均具有較好的治療作用，但佐匹克隆不良反應(yīng)少，且癥狀輕微，是短期治療老年睡眠障礙的首選藥物。

Objective To discuss the clinical efficacy of zopiclone and estazolum in treatment of elderly patients with sleep disorder. Methods Totally 200 elderly patients with sleep disorder were selected, the estazolum group (96 cases) were given estazolum, the zopiclone group (104 cases) were given zopiclone. The efficacy of zopiclone and estazolum in treatment of sleep disorder was evaluated by recording the efficacy after 2 weeks treatment, SRSS scores before and after treatment, HAMA scores before and after treatment, and adverse reactions. Results After 2 weeks treatment, the efficiencies of zopiclone group and estazolam group were 95.2% and 90.6%, without statistical significance on effective rate between two groups. Compared with the value before treatment, the scores of SRSS in two groups were decreased in two groups after two weeks treatment (P<0.05). There was no statistical significance on SRSS scores between two groups. Compared with the value before treatment, the scores of HAMA in two groups were decreased in two groups after two weeks treatment (P<0.05). But there were no statistical significance on HAMA between two groups. In two weeks treatment, the accident rate of adverse reaction in zopiclone group was lower than that of estazolum group (P<0.05). Conclusion Estazolam and zopiclone have good effect on sleep disorder. But zopiclone has less adverse reaction and mild symptoms. It is the first choice to treat elderly people with sleep disorder in short-term.