朱砂為我國常用藥材，主要成分為硫化汞（HgS）。由于汞為劇毒化合物，因此朱砂及其相關(guān)成藥的安全問題一直備受關(guān)注。查閱現(xiàn)有文獻，歸納總結(jié)朱砂及其制劑中汞的分析研究進展，包括總汞、單質(zhì)汞、可溶性汞的測定及形態(tài)分析；并探討了現(xiàn)有技術(shù)的特點，并對今后的發(fā)展做出展望，為朱砂及其制劑的科學(xué)評價和合理應(yīng)用提供參考。

Cinnabar is a commonly used medicinal material in China. Its main gradient is HgS. Since mercury is an extremely poisonous compound, safety of cinnabar and its preparations has always been a matter of great concern. Based on literature review, research development of analysis of mercury in cinnabar and its preparations was summarized, including determination of total mercury, elemental mercury, and soluble mercury as well as analysis of the speciation states. Characteristics of the current technologies were discussed and the development trend was prospected. Reference was offered for scientific evaluation and rational use of cinnabar and its preparations.

國家自然科學(xué)基金資助項目（81303194）；國家重大新藥創(chuàng)制專項（2014ZX09304307-002）