女貞子及其提取物具有降血糖、調(diào)血脂、抗肥胖作用，其活性成分主要有齊墩果酸、熊果酸、紅景天苷、酪醇、女貞子苷等單體化合物。其通過保護β細胞和刺激胰島素表達和分泌，以及對抗胰島素抵抗產(chǎn)生擬胰島素樣作用，從而刺激各種組織細胞利用葡萄糖和脂質(zhì)，促進骨、骨骼肌和棕色脂肪生長，平衡體內(nèi)脂質(zhì)、葡萄糖和能量的代謝，產(chǎn)生降低血糖、調(diào)血脂、抗肥胖的藥理作用。

Ligustri Lucidi Fructus and its extracts have hypoglycemia, lipidemic regulation, and antiobesity effects. Oleanolic acid, ursolic acid, salidroside, tyrosol, and nuezhenide are major active constituents from Ligustri Lucidi Fructus. By inducing protection of pancreatic β cell, and stimulating secretion and expression of insulin, and by antagonizing insulin resistance, and imitating insulin-like action, they stimulate utilization of glucose and lipids in various tissues and cells, and improve the homeostasis of metabolism of glucose, lipids and energy, to produce the pharmacologic effects for decreasing hyperglycemia and hyperlipemia, and antiobesity.