目的 對比分析順鉑或奈達鉑與紫醇聯(lián)合治療宮頸癌的療效。方法 選擇2012年2月-2015年12月在寧強縣天津醫(yī)院進行診治的宮頸癌患者160例，按照使用化療藥物的不同分為順鉑組和奈達鉑組。順鉑組采取TP化療方案，奈達鉑組采取TN化療方案，對比兩組的療效、化療不良反應(yīng)、住院時間和治療費用。結(jié)果 順鉑組的有效率為79.26%，與奈達鉑組的82.05%相比無明顯差異；奈達鉑組Ⅰ~Ⅳ級血紅蛋白降低、白細胞減少的發(fā)生率均明顯高于順鉑組（P<0.05），但兩組間Ⅲ~Ⅳ級血紅蛋白降低、血小板和白細胞減少發(fā)生率無明顯差異，奈達鉑組Ⅰ~Ⅳ級和Ⅲ~Ⅳ級惡心、嘔吐發(fā)生率均明顯低于順鉑組（P<0.05）；奈達鉑組患者的住院時間明顯短于順鉑組（P<0.05）；奈達鉑組的治療費用與順鉑組相比無明顯差異。結(jié)論 順鉑或奈達鉑與紫杉醇聯(lián)合應(yīng)用于宮頸癌輔助化療的療效相似，奈達鉑的胃腸道不良反應(yīng)比順鉑更低，骨髓抑制盡管增加但仍可控，采用奈達鉑化療較順鉑縮短了住院時間，且住院費用并無明顯增加，患者更易接受。

Objective To compare the effect of cisplatin or nedaplatin combined with paclitaxel as an adjuvant chemotherapy for cervical cancer. Methods Total 160 patients with cervical cancer in Ningqiang County Tianjin Hospital from February 2011 to December 2015 were divided into two groups according to different treatments. Cisplatin group was treated with TP chemotherapy, nedaplatin group was treated with TN chemotherapy, the curative effect, adverse reaction of chemotherapy, hospitalization time and treatment costs were compared between the two groups. Results The effective rate of cisplatin group was 79.26% and nedaplatin group's was 82.05%, the two groups had no significant difference; The incidence of I-IV grade hemoglobin, leukocyte of nedaplatin group were significantly higher than those in the cisplatin group (P<0.05), but between the two groups Ⅲ and IV grade had no significant difference, the incidence of I-IV grade and Ⅲ-IV grade nausea, vomiting of nedaplatin group were significantly lower than cisplatin group (P<0.05); The hospitalization time of nedaplatin group was significantly shorter than cisplatin group (P<0.05), The cost of treatment between nedaplatin group and cisplatin group had no significant difference. Conclusion Cisplatin or nedaplatin combined with paclitaxel has similar efficacy in the neoadjuvant chemotherapy for cervical cancer, gastrointestinal adverse reactions of nedaplatin are lower than cisplatin, bone marrow suppression increase but still can be controlled, nedaplatin chemotherapy can shorten the duration of hospitalization, and hospitalization expenses were not significantly increased, which makes it more easily accepted by patients.