目的 探討醫(yī)用臭氧關節(jié)腔注射聯(lián)合獨一味滴丸治療膝骨關節(jié)炎的療效。方法 選取80例膝骨關節(jié)炎患者，隨機分為2組，對照組（39例）口服獨一味滴丸治療，觀察組（41例）在口服獨一味滴丸的基礎上關節(jié)腔內注射醫(yī)用臭氧，觀察并記錄兩組患者治療后的療效、膝關節(jié)功能、炎性因子變化情況，評價獨一味滴丸聯(lián)合醫(yī)用臭氧關節(jié)腔注射治療膝骨關節(jié)炎的療效。結果 治療后觀察組有效率明顯高于對照組（P<0.05），觀察組中有38例患者治療后膝關節(jié)疼痛減輕，壓痛和腫脹癥狀有所緩解，對照組有28例。治療后觀察組在疼痛度、活動度、行走能力評分及美國膝關節(jié)協(xié)會評分（KSS）總分方面，均明顯高于對照組（P<0.05）；在穩(wěn)定性評分上相比，差異沒有統(tǒng)計學意義。治療前，兩組在IL-6、IL-8、TNF-α相比，差異沒有統(tǒng)計學意義；治療后，兩組IL-6、IL-8、TNF-α水平均明顯降低（P<0.05），且觀察組在上述指標中均明顯低于對照組（P<0.05）。結論 醫(yī)用臭氧關節(jié)腔注射聯(lián)合獨一味滴丸治療膝骨性關節(jié)炎具有較好的治療作用，能明顯緩解膝關節(jié)疼痛，提高膝關節(jié)功能，抗炎作用強，值得臨床推廣使用。

Objective To discuss the efficacy of Lamiophlomisrotata Dripping Pill combined with intra-articular injection of medical ozone in the treatment of knee osteoarthritis. Methods Eighty patients with knee osteoarthritis were selected, the control group (39 cases) were administered Lamiophlomisrotata Dripping Pill, the observation group (41 cases) were administered Lamiophlomisrotata Dripping Pill combined with intra-articular injection of medical ozone. The efficacy of Lamiophlomisrotata Dripping Pill combined with intra-articular injection of medical ozone in the treatment of knee osteoarthritis were evaluated by efficacy, knee function, and inflammatory factor. Results After treatment, the effective rate of the observation group was higher than that of the control group (P<0.05). In the observation group, there were 38 cases of patients who felt pain, tenderness, and swelling symptom relief. There were 28 cases in the control group. After treatment, the scores of pain, activity, walking ability, and KSS in the observation group were higher than that of the control group (P<0.05). There was no statistical significance on the stability between two groups. Before treatment, there were no statistical significance on the IL-6, IL-8, and TNF-α. After treatment, the IL-6, IL-8, and TNF-α were increased in two groups (P<0.05). And these indexes in the observation group were higher than that of the control group (P<0.05). Conclusion In summary, Lamiophlomisrotata Dripping Pill combined with medical ozone had good effect on the knee osteoarthritis. It could release the pain, improve knee function and anti-inflammatory. It was worthy of clinical use.