目的 研究左金丸在胃腸道調(diào)節(jié)方面的作用。方法 通過ig給予0.1%甲基橙溶液，計(jì)算其胃殘留率，觀察左金丸對(duì)小鼠胃排空的影響；通過ig 5%的炭末，計(jì)算炭末推進(jìn)率，觀察左金丸對(duì)正常小鼠小腸運(yùn)動(dòng)的影響、對(duì)新斯的明致小腸運(yùn)動(dòng)亢進(jìn)的拮抗作用；觀察左金丸對(duì)組胺致豚鼠離體回腸收縮的影響；ig給予大鼠D-木糖溶液，1 h后測(cè)定血清木糖值，觀察左金丸對(duì)大鼠小腸吸收的影響；ig給予小鼠蓖麻油，觀察左金丸的止瀉作用。以戊己丸（加味左金）和黃連有效成份小檗堿作參比。結(jié)果 左金丸對(duì)胃腸道有明顯的調(diào)節(jié)作用，延長小鼠的胃排空時(shí)間，抑制胃排空；對(duì)正常小鼠小腸運(yùn)動(dòng)的無明顯影響，但能明顯拮抗新斯的明所致的小鼠小腸運(yùn)動(dòng)亢進(jìn)；明顯抑制組胺引起的豚鼠離體回腸收縮；明顯抑制大鼠的小腸吸收功能；明顯抑制蓖麻油造成的小鼠腹瀉。結(jié)論 古方左金丸對(duì)胃腸道有明顯的調(diào)節(jié)作用，組方科學(xué)、合理。

Objective To study the effects of traditional Chinese medicine Zuojin Pill on gastrointestinal system.Methods Through ig giving 0.1% methyl orange solution, the gastric residual rate was calculated, and the effect of Zuojin Pill on gastric emptying in mice was observed. By ig administration of 5% carbon powder, the advance rate of carbon powder was calculated, and the effect of Zuojin Pill on intestinal motility in normal mice and the antagonistic effect on intestinal motility hyperfunction induced by neostigmine were observed. Effect of Zuojin Pill on contraction of isolated guinea pig ileum induced by histamine was observed. After D-xylose solution was ig given to rats, the serum xylose level was determined 1 h later, and the effect of Zuojin Pill on rat intestinal absorption was observed. The anti-diarrhea effect of Zuojin Pill was observed by giving castor oil to mice. At the same time, we have made a comparison between Zuojin Pill and Wuji Pill-berberine, to evaluate the rationalization of Zuojin Pill.Results It was obvious in experimental results that Zuojin Pill had a regulating effect on gastrointestinal system. Zuojin Pill dose-dependently inhibited the gastric emptying. Zuojin Pill demonstrated more effective suppression on the accelerated movement induced by neostigmine, but did not inhibit normal intestinal transit in mice. Zuojin Pill markedly inhibited sperm motility in mice. Zuojin Pill concentration-dependently inhibited the contraction intensity of isolated ileum muscles in guinea pigs induced by histamine. Zuojin Pill markedly inhibited diarrhea induced by castor oil. Compared with Wuji Pill-berberine, the effect of Zuojin Pill on gastrointestinal system was more visible in the same dose.Conclusion Zuojin Pill has obvious regulation effect on the gastrointestinal tract, there are indications that the application of Zuojin Pill to clinic is scientific and reasonable.