目的 觀察白脈軟膏對(duì)腦卒中的預(yù)防和治療作用，并對(duì)其可能的活血化瘀治療原則進(jìn)行初步探究。方法 白脈軟膏皮膚外涂給藥，高、中、低劑量分別為0.075、0.150、0.300 g生藥/kg，采用大鼠腦中動(dòng)脈血栓性局部缺血模型評(píng)價(jià)白脈軟膏的預(yù)防和治療作用；采用大鼠自身血腫吸收實(shí)驗(yàn)、大鼠急性血瘀模型和大鼠實(shí)驗(yàn)性體內(nèi)血栓形成實(shí)驗(yàn)評(píng)價(jià)白脈軟膏活血化瘀作用。結(jié)果 白脈軟膏皮膚外涂給藥，在0.075、0.150、0.300 g生藥/kg劑量下，對(duì)腦卒中模型大鼠無(wú)顯著預(yù)防作用；顯著改善腦卒中模型大鼠行為學(xué)評(píng)分；顯著減小大鼠自身血腫面積；顯著降低血瘀模型大鼠全血黏度及血漿黏度；顯著的延長(zhǎng)大鼠頸動(dòng)脈血栓形成時(shí)間。結(jié)論 白脈軟膏能夠顯著改善腦卒中模型大鼠行為協(xié)調(diào)性，發(fā)揮顯著治療作用，但并無(wú)顯著預(yù)防作用，初步探明其可能的中醫(yī)治療原則為活血化瘀。

Objective To observe the preventive and therapeutic effect of Baimai Ointment on stoke, and explore the principle of promoting blood circulation and removing blood stasis.Method By dermal administration, the crude drug contents of Baimai Ointment given to rats were 0.075, 0.150, and 0.300 g/kg respectively. Focal cerebral ischemic model was induced by the middle cerebral artery occlusion (MCAO), and the preventive and therapeutic effect of Baimai Ointment was evaluated. The degree of hematoma absorption in rats was measured to observe the effect on promoting blood circulation and removing blood stasis of Baimai Ointmnent. The acute blood stasis model and carotid thrombosis model were established in rats to study the effects on blood viscosity and thrombosis time.Results Baimai Ointment had no significant prevent effect on stroke in rats. It effectively improved behavior coordination in stroke model rats. It also significantly decreased the area of hematoma on rats, speeded up the repairment of local demage. After administration of Baimai Ointment, blood viscosity of blood stasis model rats was obviously decreased, while thrombosis time was effectively prolonged on carotid thrombosis model.Conclusion Baimai Ointment can significantly improve the behavior coordination in stroke model rats, plays a significant role in treatment, but no significant preventive effect, a preliminary study shows that the possible therapeutic principles may be promoting blood circulation and removing blood stasis.