目的 探討齊拉西酮聯(lián)合改良性電休克對首發(fā)精神分裂癥患者的療效及代謝的影響。方法 選擇2013年7月-2016年7月新鄉(xiāng)醫(yī)學(xué)院第二附屬醫(yī)院收治的86例首發(fā)精神分裂癥患者，根據(jù)隨機(jī)數(shù)字表法，分為觀察組及對照組，觀察組給予齊拉西酮聯(lián)合改良性電休克治療，對照組給予奧氮平聯(lián)合改良性電休克治療。觀察對比兩組患者的PANSS總評分、CGI評分、總有效率、不良反應(yīng)、體質(zhì)指數(shù)（BMI）、糖代謝及脂代謝。結(jié)果 治療后，兩組的PANSS總評分、CGI評分均明顯下降，且組間對比差異無統(tǒng)計學(xué)意義；兩組總有效率對比無明顯差異；治療后兩組TESS評分均明顯降低，治療后觀察組的TESS評分明顯低于對照組（P<0.05）；與治療前比較，治療后觀察組的BMI、空腹血糖、三酰甘油、總膽固醇、高/低密度脂蛋白、胰島素水平均無明顯變化，而對照組的BMI、空腹血糖、三酰甘油、總膽固醇、低密度脂蛋白、胰島素水平與治療前相比顯著升高；觀察組治療后BMI、空腹血糖、三酰甘油、總膽固醇、胰島素水平明顯低于對照組（P<0.05）。結(jié)論 奧氮平與齊拉西酮聯(lián)合改良型電休克治療首發(fā)精神分裂癥患者均有顯著療效，而齊拉西酮的不良反應(yīng)及代謝副反應(yīng)少，值得臨床推廣應(yīng)用。

Objective To investigate the influence of ziprasidone combined with amend electric shock on the efficacy and metabolism of patients with first-episode schizophrenia.Methods According to random number table, 86 cases with first-episode schizophrenia from July 2013 to July 2016 in the Second Affiliated Hospital of Xinxiang Medical University were chosen and divided into observation group and control group. The patients in observation group were given ziprasidone combined with first-episode schizophrenia, the patients in control group were taken with olanzapine combined with first-episode schizophrenia. The PANSS total score, CGI score, total efficacy, adverse reaction, body mass index, glycometabolism, and lipid metabolism of two groups were observed and compared.Results The PANSS score, CGI score of two groups were all obvious decreased, which had no significant difference, the total efficacy of two groups had no significant difference; The TESS scores were all decreased, and the TESS score of observation group was obviously lower than that of control group (P<0.05). Compared with before treatment, the BMI, fasting blood sugar, triglyceride, total cholesterol, high/low density lipoprotein and fasting insulin level of observation group after treatment had no obvious significant difference, while the BMI, fasting blood sugar, triglyceride, total cholesterol, low density lipoprotein, and fasting insulin levels of control group had obvious significant difference, and the BMI, fasting blood sugar, triglyceride, total cholesterol, and fasting insulin of observation group were obviously lower than control group (P<0.05).Conclusion Olanzapine and ziprasidone combined with amend electric shock have obvious efficacy on patients with first-episode schizophrenia, while the ziprasidone had lower adverse reaction and metabolic side effects, which is worth of clinical promotion and application.