131I治療甲狀腺功能亢進(jìn)的療效及安全性。方法 收取2012年6月-2015年6月之間西安交通大學(xué)附屬三二0一醫(yī)院收治的甲狀腺功能亢進(jìn)患者83例作為研究對(duì)象,根據(jù)隨機(jī)數(shù)字表法將其分為觀察組42例及對(duì)照組41例,觀察組予以甲巰咪唑聯(lián)合131I治療,對(duì)照組予以丙硫氧嘧啶聯(lián)合131I治療。對(duì)兩組患者臨床療效、用藥前后甲狀腺血清學(xué)指標(biāo)、不良反應(yīng)以及復(fù)發(fā)率進(jìn)行考察與對(duì)比。結(jié)果 觀察組患者臨床治療總有效率為95.24%,遠(yuǎn)遠(yuǎn)高于對(duì)照組的70.73%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。治療后兩組患者血清促甲狀腺素(TSH)較治療前升高,三碘甲腺原氨酸(T3)、甲狀腺素(T4)、游離三碘甲腺原氨酸(FT3)、游離甲狀腺素(FT4)、促甲狀腺素受體抗體(TRAb)以及甲狀腺過氧化物酶抗體(TPOAb)均較治療前下降;且觀察組TSH明顯高于對(duì)照組,T3、T4、FT3、FT4明顯低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。觀察組患者總不良反應(yīng)發(fā)生率(14.29%)顯著低于對(duì)照組(46.34%),差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。觀察組復(fù)發(fā)率(4.76%)明顯低于對(duì)照組(26.83%),差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 甲巰咪唑聯(lián)合131I治療甲狀腺功能亢進(jìn)患者療效及安全性好,值得臨床推廣應(yīng)用。;Objective To explore the clinical effect and safety of methimazole combined with 131I in treatment of hyperthyroidism.Methods Patients (83 cases) with hyperthyroidism accepted in Xi'an Jiaotong University Affiliated San Er Ling Yi Hospital from June 2012 to June 2015 were selected and divided into observation group with 42 cases and control group with 41 cases. Patients in observation group were given methimazole combined with 131I, and patients in control group were given PTU combined with 131I. Then the clinical effect, thyroid gland serological indexes, adverse reations, and reoccurrence rates of two groups were observed and compared.Results The total clinical efficacy of observation group was 95.24%, which was obviously higher than 70.73% of control group with statistically significance (P<0.05). TSH was getting higher after treatment of two groups, and T3, T4, FT3, FT4, TRAb, and TPOAb were getting lower after treatment of two groups. And TSH in the observation group was significantly higher than that in the control group, T3, T4, FT3, and FT4 were significantly lower than those in the control group (P<0.05). The adverse reaction rate of observation group (14.29%) was obviously lower than that of control group (46.34%) with statistically significance (P<0.05). The reoccurrence rate of observation group (4.76%) was obviously lower than that of control group (26.83%) with statistically significance (P<0.05).Conclusion Methimazole combined with 131I has good effect and safety in treatment of hyperthyroidism, which is worth of clinical application."/> 131I"/>