目的 探究氧驅(qū)動霧化吸入普米克令舒聯(lián)合孟魯司特治療小兒哮喘的有效性及對肺功能、T淋巴細(xì)胞亞群的影響。方法 選擇惠州市中心人民醫(yī)院2014年6月-2016年6月收治的78例小兒哮喘患者，根據(jù)隨機(jī)數(shù)字表法，分為觀察組和對照組，每組39例。對照組在常規(guī)治療基礎(chǔ)上以氧驅(qū)動霧化吸入普米克令舒1.0 mg，2次/d，觀察組在對照組基礎(chǔ)上再加服孟魯司特鈉咀嚼片5 mg/次，1次/d，1周為1個(gè)療程。比較兩組患者臨床療效、癥狀評分、肺功能、細(xì)胞免疫水平。結(jié)果 觀察組的總有效率為94.70%，顯著高于對照組的總有效率82.05%（P<0.05）；治療后，兩組患兒癥狀評分均顯著降低（P<0.05），且觀察組的癥狀評分顯著低于對照組（P<0.05）；兩組患兒的肺功能均有明顯改善，且觀察組患者的FEV1、FVC以及FEV1/FVC水平顯著高于對照組（P<0.05）；對照組的細(xì)胞免疫水平無明顯改善，觀察組患者的CD₄⁺以及CD₄⁺/CD₈⁺水平與治療前相比均明顯降低，CD₈⁺水平顯著提升（P<0.05）。結(jié)論 氧驅(qū)動霧化吸入普米克令舒聯(lián)合孟魯司特治療小兒哮喘臨床效果顯著，對機(jī)體免疫水平具有正向調(diào)節(jié)作用，值得臨床推廣。

Objective To explore the validity of oxygen atomizing inhalation pulmicort respulas combined with montelukast in treating children with asthma and its role in pulmonary function and T lymphocyte subset. Methods Totally 78 cases treated in Huizhou People's Hospital from June, 2014 to June, 2016 were randomly divided into observation group and control group with each group of 39 cases. The control group on the basis of routine treatment with oxygen atomizing inhalation of pulmicort 1 mg, twice daily, and the observation group based on control group added Montelukast Sodium Chewable Tablets 5 mg, once daily, one week for one course. The clinical effect, pulmonary function, and level of T lymphocyte subset were compared between two groups. Results The total effective rate in the observation group was 94.70%, which was significantly higher than control group (82.05%, P<0.05). After therapy, the symptom scores of two groups were obviously decreased compared with those before therapy (P<0.05), and those of the observation group were significantly lower than control group (P<0.05); The pulmonary function of the two groups were obviously improved (P<0.05) compared with that before therapy (P<0.05), and the levels of FEV1, FVC, and FEV1/FVC in observation group were significantly higher than control group (P<0.05); The level of T lymphocyte subset in control group showed no statistical difference compared to that before therapy, and the levels of CD₄⁺and CD₄⁺/CD₈⁺in observation group were obviously decreased, whereas CD₈⁺was increased. Conclusion Oxygen atomizing inhalation pulmicort respulas combined with montelukast could effectively increase the clinical effect on children with asthma, improve pulmonary function and positively regulate immune function, which deserves clinical expansion.