目的 探討阿托伐他汀致不良反應(yīng)的一般規(guī)律與特點，為臨床合理用藥提供參考。方法 回顧性對福建省長樂市醫(yī)院2008年1月-2016年5月收集阿托伐他汀所致的ADR報告表進行統(tǒng)計、分析。結(jié)果 阿托伐他汀引起的不良反應(yīng)共計52例。所致不良反應(yīng)發(fā)生次數(shù)最多為肝膽系統(tǒng)損害22次（37.29%），胃腸系統(tǒng)損害11次（18.64%），全身性損害5次（8.47%），肌肉骨骼系統(tǒng)損害5次（8.47%），心肌、心內(nèi)膜、心包及瓣膜損害4次（6.78%），聽覺和前庭功能損害4次（6.78%）。結(jié)論 臨床上應(yīng)加強阿托伐他汀應(yīng)用的監(jiān)測，以減少不良反應(yīng)的發(fā)生。

Objective To explore the general rules and characteristics of adverse reactions induced by atorvastatin, and to provide reference for clinical rational use of drugs. Method A retrospective analysis was made on the statistics and analysis of the ADR report forms collected in Fujian Changle Hospital from January 2008 to May 2016. Results The adverse reactions induced by atorvastatin were 52 cases. The number of adverse reactions was up to a maximum of hepatobiliary system damage 22 times (37.29%), gastrointestinal system damage 11 times (18.64%), systemic damage 5 times (8.47%), musculoskeletal system damage 5 times (8.47%), myocardium, endocardium, pericardial and valvular damage 4 times (6.78%), auditory and vestibular function damage 4 times (6.78%). Conclusion The clinical application of atorvastatin should be strengthened in order to reduce the occurrence of adverse reactions.