目的觀察小枝玫瑰Branchlets Rosa rugosa Thunb.提取物對四氧嘧啶糖尿病小鼠血糖及糖耐量的影響。方法采用四氧嘧啶造模法建立糖尿病小鼠模型,將造模成功的小鼠分為8組,分別為模型組,小枝玫瑰水提物高、中、低劑量（3.70、1.85、0.93 g/kg）組,小枝玫瑰醇提物高、中、低劑量（2.75、1.37、0.70 g/kg）組和鹽酸二甲雙胍（陽性藥,200 mg/kg）組,另取正常小鼠為對照組,造模成功3 d后開始給藥,每天ig給藥1次,共30 d。造模后0、10、20、28 d血糖試紙法測定空腹血糖；造模后30 d,進(jìn)行葡萄糖耐量試驗。結(jié)果各組小枝玫瑰提取物均能降低糖尿病小鼠血糖、改善其糖耐量,且呈一定量效關(guān)系,其中以醇提物高劑量效果最好,但不及陽性藥鹽酸二甲雙胍。結(jié)論小枝玫瑰提取物可以降低糖尿病小鼠血糖,對糖尿病小鼠糖耐量有改善作用。

Objective To observe the effect of extract from Branchlets roses on blood glucose and glucose tolerance in diabetes mice induced by alloxan.Methods Diabetes animal model was established by alloxan.Dividing the model mice into eight groups:model group,water extract high,middle,and low dose (3.70,1.85,and 0.93 g/kg) group,and ethanol extract high,middle,and low dose (2.75,1.37,and 0.70 g/kg) group,and metformin (positive drug,200 mg/kg) group,and normal mice were taken as control group.Drug was ig administered to mice 3 d after molding once daily.Blood glucose test paper was used to determine fasting blood glucose 0,10,20,and 28 d after modeling,and the glucose tolerance test was performed 30 d after modeling.Results The extract of Branchlets roses from all the groups could decrease the blood glucose and improve the glucose tolerance,and showed a certain dose-effect relationship.In all the extracts,the alcohol extract had the best effect,but the effect was not as good as the positive control drug metformin hydrochloride group.Conclusion The extract of Branchlets roses can reduce the blood sugar content of diabetic mice,and improve the glucose tolerance.

新疆維吾爾自治區(qū)中小企業(yè)技術(shù)創(chuàng)新基金資助項目（201253217）