目的探討分析丁苯酞對急性腦梗死患者NT-proBNP水平和血清炎癥因子的影響。方法選擇2014年3月-2016年5月在衡水市第五人民醫(yī)院神經(jīng)內(nèi)科接受治療的118例急性腦梗死患者,隨機(jī)分為對照組60例和觀察組58例。對照組給予常規(guī)藥物治療,觀察組在對照組的基礎(chǔ)上給予丁苯酞注射液治療。觀察治療前及治療7、14 d后兩組患者的血漿N末端B型腦鈉肽前體（NT-proBNP）水平、美國國立衛(wèi)生研究院卒中量表（NIHSS）和血清炎癥因子包括超敏C反應(yīng)蛋白（hypersensitiveC-reactive protein,hs-CRP）、白細(xì)胞介素-6（interleukin-6,IL-6）及腫瘤壞死因子-α（tumor necrosis factor-α,TNF-α）,以及不良反應(yīng)發(fā)生情況。結(jié)果治療前,兩組患者的血漿NT-proBNP水平、NIHSS評分以及血清炎癥因子水平比較差異無統(tǒng)計學(xué)意義。治療7、14 d后,兩組NT-proBNP水平、NIHSS評分均明顯降低,與治療前比較差異顯著（P<0.05）；治療7、14 d后,觀察組的NT-proBNP水平顯著低于對照組（P<0.05）；治療14 d后,觀察組的NIHSS評分顯著低于對照組,比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療前,兩組的hs-CRP、IL-6、TNF-α比較差異無統(tǒng)計學(xué)意義；治療7、14 d后,兩組的hs-CRP、IL-6、TNF-α水平均明顯降低,與治療前比較差異顯著（P<0.05）；且觀察組的以上3個血清炎癥因子水平均顯著低于對照組,兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論丁苯酞可有效抑制急性腦梗死患者的血漿NT-proBNP水平及血清炎癥因子水平,改善患者神經(jīng)功能預(yù)后。

Objective To investigate the clinical efficacy of dl-3n-butylphthalide and its effect on NT-proBNP levels and inflammatory cytokines of patients with acute cerebral infarction. Methods Total 118 patients with acute cerebral infarction in Hengshui Fifth People's Hospital were randomly divided into control group and observation group. Sixty patients in control group were treated with conventional medication, and 58 patients in observation group were treated with dl-3n-butylphthalide injection based on conventional medication. The NT-proBNP levels, score of neurological deficits (NIHSS), inflammatory cytokines including hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) before and after 7 and 14 d of treatment, and adverse reaction were observed and analyzed. Results Before treatment, differences in the NT-proBNP levels, NIHSS score, hs-CRP, IL-6, and TNF-α between two groups were not obvious. After 7 and 14 d of treatment, NT-proBNP levels in observation group were significantly lower than those in control group (P < 0.05). And after treatment for 14 d, NIHSS score in observation group were conspicuously lower than those in control group (P < 0.05). Additionally, the levels of hs-CRP, IL-6, and TNF-α in observation group were markedly lower than those in control group (P < 0.05). Conclusion Dl-3n-butylphthalide injection has a good ability in inhibiting NT-proBNP levels and inflammatory cytokines, and improves the neurological function of patients with acute cerebral infarction.