目的觀察穩(wěn)心顆粒聯(lián)合富馬酸比索洛爾治療心力衰竭合并室性早搏的臨床療效。方法選擇2013年1月-2016年1月在兵團(tuán)第七師醫(yī)院收治的心力衰竭合并室性早搏的患者132例,隨機(jī)分為兩組,每組66例。富馬酸比索洛爾組（BF組）患者接受富馬酸比索洛爾治療,口服5 mg/次,每天1次；穩(wěn)心顆粒聯(lián)合富馬酸比索洛爾（BW）組患者在BF組治療基礎(chǔ)上服用穩(wěn)心顆粒,溫水沖服,9 g/次,每天3次,所有患者服用4周。監(jiān)測(cè)患者心電圖并進(jìn)行心臟超聲檢查,同時(shí)測(cè)定患者治療前后血漿氨基末端B型利鈉肽前體（NT-proBNP）的濃度并測(cè)定血液流變學(xué)指標(biāo)。結(jié)果比較兩組患者治療后的心臟超聲結(jié)果,BW組患者的心室功能恢復(fù)情況明顯優(yōu)于BF組（P<0.05）；BW組患者臨床癥狀、室性早搏、心衰療效的總有效率較BF組更高（P<0.05）。BW組患者全血黏度、血漿黏度、血漿纖維蛋白原等血液流變學(xué)指標(biāo)以及血漿NT-proBNP的濃度明顯低于BF組（P<0.05）。結(jié)論穩(wěn)心顆粒聯(lián)合富馬酸比索洛爾較富馬酸比索洛爾單一用藥治療心力衰竭合并室性早搏臨床療效改善更顯著,且用藥相對(duì)安全。

Objective To explore the curative effect of bisoprolol fumarate combined with wenxin granule for patients with heart failure complicated with premature ventricular. Methods 132 patients with heart failure and premature ventricular complexes were enrolled in our hospital from January 2013 to January 2016, and which patients divided into two groups, bisoprolol fumarate group (Group BF, n=66) accepted bisoprolol fumarate treatment (5 mg/time, 1 times/day), and bisoprolol fumarate combined with wenxin granule group (Group BW n=66) adopted wenxin granule (9 g/time, 3 times/day) based on the patients in Group BF. After 4 weeks treatment, the curative effect of all patients were evaluated with electrocardiogram monitor and cardiac ultrasound examination, and the plasma NT-proBNP concentration and hemorheology indexes were analyzed compared with pre-treatment. Results The recovery of ventricular function in Group BW was better significantly than that patients in Group BF from the cardiac ultrasound examination (P < 0.05); The total relieved effective of clinical symptom, premature ventricular complexes and heart failure in Group BW were more remarkable than those in Group BF, and which difference from them was significance (P < 0.05); The blood viscosity, plasma viscosity, plasma fibrinogen and plasma NT-proBNP concentration in patients with Group BW were significantly lower than those Group BF (P < 0.05). Conclusions The clinical curative effect of bisoprolol fumarate combined with Wenxin Granule for heart failure complicated with premature ventricular was more remarkable compare with bisoprolol fumarate single treatment, and which possessed the relative safety.