目的評價殼聚糖對臨床手術(shù)創(chuàng)面修復的有效性及安全性。方法檢索Cochrane圖書館臨床對照試驗資料庫（CCTR）,Medline、Embase、PubMed數(shù)據(jù)庫,中國期刊全文數(shù)據(jù)庫（CNKI）、萬方數(shù)字化期刊全文庫、中文科技期刊全文數(shù)據(jù)庫（VIP）和中文生物醫(yī)學期刊文獻庫（CMCC）,收集殼聚糖修復手術(shù)創(chuàng)面的隨機對照臨床試驗,使用RevMan 5.0軟件進行Meta分析。結(jié)果共納入16項研究,3 414例患者。Meta分析結(jié)果顯示：殼聚糖對手術(shù)創(chuàng)面修復的愈合時間明顯短于對照組[WMD=-0.64,95%CI（-0.69~-0.59）,P<0.000 01],且能更好地促進切口愈合[RR=1.03,95%CI（1.01~1.04）,P=0.0002]；明顯減輕術(shù)后疼痛[WMD=-3.49,95%CI（-5.07~-1.91）,P<0.000 1]；減少術(shù)后感染[RR=0.49,95% CI：0.33~0.71,P=0.000 2]。結(jié)論殼聚糖能縮短術(shù)后傷口愈合時間,更好地促進傷口愈合,減輕疼痛,減少感染；但納入的研究質(zhì)量均不高,仍亟需更多高質(zhì)量的臨床試驗進一步驗證殼聚糖對臨床手術(shù)后創(chuàng)面修復的有效性和安全性。

Objective To evaluate the efficacy and safety of chitosan in the repair of clinical surgery wounds. Methods The databases of Cochrane Controlled Trials Register (CCTR), Embase database, Medline database, PubMed database, CNKI database, WanFang database, VIP database and Chinese Biomedical Journal Library (CMCC) were retrieved with computer for collecting randomized controlled trials (RCT) about the repair clinical surgery wounds healing. Meta-analysis on all the data are carried out by RevMan 5.0 software. Results There were totally 16 trials and 3414 patients included. The results showed that the wound healing time of chitosan was significantly shorter than that of the control group[WMD=-0.64, 95%CI (-0.69~-0.59), P < 0.000 01], and chitosan can better promote wound healing[RR=1.03, 95%CI (1.01~1.04), P=0.0002]. In experimental group, postoperative pain were reliever[WMD=-3.49, 95%CI (-5.07~-1.91), P < 0.0001], and postoperative infection were reduced[RR=0.49, 95%CI (0.33~0.71), P=0.0002]. Conclusion The existing evidences indicate that chitosan can shorten postoperative wound healing time, promote wound healing, relieve pain, and reduce infection. However, the study is limited by the quality of included literature, more clinical trials should be done to confirm the effective and safety.

福建省科技廳高校產(chǎn)學合作項目（2015Y4006）；福建中醫(yī)藥大學校管課題（XB2015001）