柚皮苷主要存在于蕓香科柑橘屬植物柚、葡萄柚、酸橙及其變種的果皮及果實(shí)中,屬于雙氫黃酮類化合物。研究表明柚皮苷具有抗1型及2型糖尿病的藥理作用,作用機(jī)制為通過抑制糖尿病相關(guān)的氧化應(yīng)激損傷、炎癥、糖代謝酶異常等方面,同時(shí)在一定程度上延緩糖尿病并發(fā)癥（包括糖尿病心肌病、糖尿病腎病、糖尿病視網(wǎng)膜病變及糖尿病神經(jīng)病變）的發(fā)生與發(fā)展。探討柚皮苷對糖尿病及其并發(fā)癥作用機(jī)制的研究進(jìn)展,旨在為抗糖尿病新藥研發(fā)提供依據(jù)。

Naringin is mainly present in Rutaceae Citrus Pomelo, grapefruit, lime, and its variants of the peel and fruit, which belongs to dihydrogen flavonoids. Studies have shown that naringin has anti-type 1 and type 2 diabetes pharmacological effects, the mechanism of action by inhibiting diabetes-related oxidative stress injury, inflammation, abnormal metabolism of glucose, and other aspects, while a certain degree of delay in diabetes complications (including diabetic cardiomyopathy, diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy). The mechanism of naringin on the mechanism of diabetes mellitus and its complications was studied in order to provide the basis for the development of antidiabetic drug.

國家自然科學(xué)基金（81573216），研究生創(chuàng)新科研項(xiàng)目（2016YJSCX-23MY），牡丹江醫(yī)學(xué)院科研項(xiàng)目（ZS201518）