女貞子及其活性成分熊果酸、紅景天苷等具有胰島素樣作用,對(duì)骨骼肌產(chǎn)生正性作用,即促進(jìn)骨骼肌利用糖和脂質(zhì),增強(qiáng)肌糖原和肌蛋白合成,增加骨骼肌質(zhì)量、快肌纖維和慢肌纖維體積,并促進(jìn)快肌纖維向慢肌纖維轉(zhuǎn)化。熊果酸還能刺激肌衛(wèi)星細(xì)胞增殖、成肌細(xì)胞肌性分化,促進(jìn)骨骼肌中新的肌細(xì)胞生長(zhǎng),促使骨骼肌強(qiáng)壯。其次,女貞子及其活性成分下調(diào)骨骼肌特異性的肌肉萎縮素-1和肌肉環(huán)狀指蛋白表達(dá),及其抗氧化應(yīng)激和抗炎作用,最終可以防治肌萎縮和疲勞引起的骨骼肌損傷。

Ligustri Lucidi Fructus and its active constituents, ursolic acid and salidroside, have insulin-like effect to produce positive action on skeletal muscle:, It can improve the utilization of carbohydrate and lipid in muscle, increase synthesis of muscular glycogen and protein, muscular weigh, size of fast-and slow-muscle fibers, and accelerate transformation fast-muscle fiber toward slow-muscle fiber. Ursolic acid stimulates muscle satellite cells proliferation, myogenic differentiation of myoblasts, enhances neomyogenesis in skeletal muscle, and promotes skeletal muscle rejuvenation. In addition, Ligustri Lucidi Fructus and its active constituents down-regulating repression of atrogin-1 and muscle ring-finger protein-1 (MuRF-1), and anti-oxidation and anti-inflammation, it may protect and treat for muscle atrophy and fatigue-induced muscle injury.