目的 探究熱毒寧注射液聯(lián)合脾氨肽口服液治療小兒手足口病的療效及對機體心肌酶、免疫水平的調(diào)節(jié)作用。方法 選擇2014年9月—2016年9月期間開封市兒童醫(yī)院收治的184例小兒手足口病患兒，按照入院就診順序?qū)?84例患兒分為觀察組和對照組，每組92例，另選擇20名年齡、性別匹配的健康體檢兒童為健康組。對照組給予常規(guī)治療，觀察組在對照組基礎(chǔ)上給予熱毒寧注射液聯(lián)合脾氨肽口服液治療。比較兩組患者的臨床有效率、心肌酶、炎癥因子、免疫水平。結(jié)果 觀察組患者臨床總有效率為93.48%（86/92），對照組患者的臨床總有效率為80.43%（74/92），觀察組患者的臨床療效明顯優(yōu)于對照組（P＜0.05）；治療后，觀察組患兒血清hs-cTnT、CK-MB、CK、TNF-α、IL-6、CRP、CD3⁺、CD4⁺、CD8⁺、IgA、IgM、IgG與健康組比較，差異無統(tǒng)計學意義；對照組上述指標與治療前相比，顯著改善，然而與健康組比較，仍具有顯著性差異（P＜0.05）。結(jié)論 熱毒寧聯(lián)合脾氨肽可有效控制手足口病患兒全身炎癥反應(yīng)，修復(fù)心肌損傷，臨床療效確切，值得臨床推廣。

Objective To investigate the effect of Reduning Injection (RI) combined with spleen aminopeptide oral solution on children with hand-foot-and-mouth disease and its regulative effect on myocardial enzyme and inflammatory level. Methods Totally 184 cases treated in Children's Hospital of Kaifeng City from September, 2014 to September, 2016 were randomly divided into observation group and control group with each group of 92 cases. Control group was given conventional therapy, on the basis of which, observation group was given RI combined with spleen aminopeptide oral solution. Clinical effect and levels of inflammatory cytokine and myocardial enzyme were compared between the two groups. Results The total effective rate in observation group was 93.48%, which was significantly higher than that in control group (80.43%) (P< 0.05). After therapy, the levels of hs-cTnT, CK-MB, CK, TNF-α, IL-6, CRP, CD3⁺, CD4⁺, CD8⁺, IgA, IgM, and IgG in observation group showed no statistical difference compared with healthy group. Index mentioned above of control group were significantly improved, however there were still statistical difference compared with healthy group (P< 0.05). Conclusion RI combined with spleen aminopeptide oral solution could effectively decrease the levels of inflammatory cytokine as well as myocardial enzyme, which deserves clinical expansion.