絞股藍(lán)皂苷為絞股藍(lán)的主要活性成分，屬于達(dá)瑪烷型四環(huán)三萜，其在藥材中含量高、容易獲得，主要生物活性體現(xiàn)在抗腫瘤、降血糖、降血脂、心腦血管保護(hù)等方面。絞股藍(lán)皂苷易受酸、堿、酶的影響而降解，水解后不僅脫去糖生成次級(jí)苷，而且苷元的結(jié)構(gòu)也會(huì)發(fā)生變化。查閱近年來國(guó)內(nèi)外文獻(xiàn)并進(jìn)行歸納總結(jié)，綜述絞股藍(lán)皂苷水解產(chǎn)物化學(xué)結(jié)構(gòu)與藥理作用的研究進(jìn)展，為尋找結(jié)構(gòu)新穎、活性更強(qiáng)的先導(dǎo)化合物提供參考。

The biologically active constituents in Gynostemma pentaphyllum are dammarane-type glycosides, called gypenosides. They are believed to be the highest contents of this herb, easy to obtain, and mainly active in anti-tumor, controlling the blood glucose, lipid-lowering, cardiovascular protection, etc. The saponins may change into sub-glucoside after hydrolysis, for the internal acetal glucoside structure is vulnerable to acid, alkali, and enzyme degradation. Through searching the literatures in recent years, this paper summarized the chemical constituents in the hydrolyzed products of gypenosides, for providing references to discover novel and more active lead compounds.

國(guó)家自然科學(xué)基金青年科學(xué)基金（81602983），遼寧省自然科學(xué)基金優(yōu)秀人才培養(yǎng)項(xiàng)目（2015020698）