目的 比較地榆烘法制炭前后的止血作用。方法 昆明小鼠60只，隨機(jī)分為6組：對照組，云南白藥（陽性藥，0.667 g/kg）組，地榆高、低劑量（8、2 g生藥/kg）組，地榆炭高、低劑量（8、2 g生藥/kg）組，每天ig給藥1次，連續(xù)給藥3 d，于末次給藥1 h后檢測小鼠出血時(shí)間、凝血時(shí)間，血凝儀檢測凝血酶原時(shí)間（PT）、凝血酶時(shí)間（TT）、活化部分凝血活酶時(shí)間（APTT），進(jìn)行血小板計(jì)數(shù)。結(jié)果 與對照組比較，高劑量地榆和烘制的高、低劑量地榆炭顯著縮短小鼠的出血時(shí)間、凝血時(shí)間、PT、TT和APTT；高、低劑量地榆和高劑量地榆炭顯著提高血小板計(jì)數(shù)；與地榆高劑量組比較，高劑量地榆炭能顯著縮短小鼠的PT、TT、出血和凝血時(shí)間，對血小板數(shù)量和APTT的影響差異不顯著。結(jié)論 地榆烘法制炭后止血作用增強(qiáng)。

Objective To compare the hemostasis effect of Sanguisorbae Radix(SR)and charred Sanguisorbae Radix(CSR) before and after baking. Methods Totally 60 Kunming mice were randomly divided into six groups: control group, Yunnan Baiyao (positive drug group, 0.667 g/kg), SR high and low dose (8, 2 gcrude drug/kg) group, and CSR high and low dose (8, 2 gcrude drug/kg) group. Mice were continuously ig with relatively drug once a day for 3 d. The bleeding time and clotting time were tested 1 h after the last administration, the prothrombin time (PT), thrombin time (TT), and activated partial thromboplastin time (APTT) were detected by blood coagulation analyzer, and the number of platelet was count. Results Compared with control group, SR of high dose, and CSR of high and low doses can obviously shorten the bleeding time, clotting time, PT,TT, and APTT. SR of high and low dosesand CSR of high dose can elevate the blood platelets count. Compared with SR high dose group, CSR of high dose can obviously shorten the PT,TT, bleeding time, and clotting time, but could not be statistically significant on the blood platelets count and APTT. Conclusion SR and CSR have different hemostasis mechanisms, the function of hemostasis was more effective after charcoal by baking.

邯鄲市科學(xué)技術(shù)研究與發(fā)展計(jì)劃（1523108076-8）