目的 對比泮托拉唑與奧美拉唑治療消化道潰瘍出血的療效。方法 選取80例消化道潰瘍患者，隨機分為兩組，觀察組靜脈滴注泮托拉唑，對照組靜脈滴注奧美拉唑，兩組均治療7 d。觀察并記錄兩組患者治療后的療效、治療前后胃液pH值、出血時間、住院時間及出血量和治療期間不良反應情況，評價奧美拉唑與泮托拉唑治療消化道潰瘍出血的療效及安全性。結果 觀察組有效率92.7%，對照組有效率89.7%，兩組治療有效率無明顯差異；但觀察組顯效率（85.4%）明顯高于對照組（56.4%），差異有統(tǒng)計學意義（P<0.05）。治療前兩組胃液呈酸性，pH值相比無統(tǒng)計學差異，治療后兩組胃液pH有所提高，觀察組胃液pH值高于對照組，差異有統(tǒng)計學意義（P<0.05）。觀察組患者住院時間、止血時間均短于對照組，差異有統(tǒng)計學意義（P<0.05）；出血量明顯少于對照組，差異有統(tǒng)計學意義（P<0.05）。治療期間，觀察組患者不良反應明顯少于對照組，差異有統(tǒng)計學意義（P<0.05）。結論 泮托拉唑與奧美拉唑均適用于消化道潰瘍出血的治療，但泮托拉唑抗酸和止血效果更好，藥物安全性更高，值得臨床推廣使用。

Objective To discuss the efficacy of omeprazole and pantoprazole in treatment of peptic ulcer hemorrhage. Methods 80 patients with peptic ulcer hemorrhage were selected, they were divided into two groups randomly. The observation group(41 cases) was given pantoprazole by intravenous drip. The control group(39 cases) was given omeprazole by intravenous drip. The efficacy and safety of omeprazole and pantoprazole in treatment of peptic ulcer hemorrhage was evaluated by efficacy, pH before and after treatment, bleeding time, hospitalization and bleeding volume, and adverse reaction during treatment. Results The effective rate was 92.7% in the observation group and 89.7% in the control group. There was no statistical significance on effective rate between two groups. But the excellent rate of observation group was higher than that of the control group(P<0.05). Before treatment, the gastric acid was acidic. There were no statistical significance on pH value between two groups. After treatment, the pH value was increased in two groups. The pH value of observation group was higher than that of the control group(P<0.05). The hospitalization, hemostasis time and bleeding volume was shorter than that of the control group(P<0.05). During treatment, the patients given pantoprazole had less adverse reaction(P<0.05). Conclusion Pantoprazole and omeprazole are suitable for treating peptic ulcer hemorrhage. But the antacid and hemostatic effect of pantoprazole was better with high safety. It was worthy of clinical application.