目的 探討西咪替丁聯(lián)合阿昔洛韋治療小兒水痘的臨床療效。方法 選取80例水痘患兒，隨機(jī)數(shù)字表法分為兩組，對照組患兒（40例）靜脈滴注阿昔洛韋注射液15 mg/（kg·d），觀察組患兒（40例）靜脈滴注西咪替丁注射液和阿昔洛韋注射液各15 mg/（kg·d），兩組均治療7 d。觀察并記錄兩組患兒臨床療效，治療后患兒退熱時間、皮疹結(jié)痂時間、瘙癢消失時間，治療前后HAMA評分及治療期間不良反應(yīng)情況，評價西咪替丁聯(lián)合阿昔洛韋治療小兒水痘的臨床療效。結(jié)果 觀察組治療有效率87.5%，對照組治療有效率65.0%，觀察組治療有效率高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后觀察組患兒退熱時間、皮疹結(jié)痂時間、瘙癢消失時間均短于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療前，兩組患兒HAMA評分相比，無統(tǒng)計學(xué)差異；治療后，兩組患兒HAMA評分均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組明顯低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療期間，兩組不良反應(yīng)率無明顯差異。結(jié)論 西咪替丁聯(lián)合阿昔洛韋治療小兒水痘效果良好，能較快改善水痘臨床癥狀，減輕小兒焦慮情緒，治療方案安全性高，值得臨床推廣使用。

Objective To discuss the efficacy of cimetidine combined with acyclovir in treatment of children with varicella. Methods 80 cases of varicella were randomly divided into two groups. The observation group (40 cases)was treated with cimetidine combined with acyclovir treatment. The control group (40 cases)was given the acyclovir. Observe and record the two groups of children with clinical efficacy, fever time, rash scab, itching disappeared time after treatment, before and after treatment during the HAMA score and the treatment of adverse reactions. The clinical curative effect of cimetidine combined with acyclovir in treatment of children with varicella was evaluated. Results The observation group of total effective rate was 87.5%. The control group of total effective rate was 65%. The total effective rate of observation group was higher than the control group, the difference was statistically significant (P<0.05). After treatment, the fever time, skin rash, scab time and pruritus disappeared in the observation group were shorter than those in the control group, the difference was statistically significant (P<0.05).Before treatment, there was no statistical difference in HAMA scores between the two groups. After treatment, the scores of HAMA in the two groups were significantly lower than those in the same group before and after treatment (P<0.05), and the treatment group was significantly lower than the control group, the difference was statistically significant (P< 0.05).There was no significant difference in adverse reactions between the two groups during the treatment.Conclusion Cimetidine combined with acyclovir have a good therapeutic effect on varicella. They can rapidly improve the clinical symptoms of pediatric varicella, reduce anxiety with high safety. It is worthy of clinical use.