目的 研究廣西地不容Stephania kwangsiensis總生物堿（TARS）的體內(nèi)鎮(zhèn)痛抗炎作用。方法 清潔級昆明種小鼠按性別、體質(zhì)量分層隨機分為5組：對照組（等體積蒸餾水），TARS低、中、高劑量（0.15、0.20、0.25 g/kg）組，阿司匹林（陽性對照，0.2 g/kg）組。采用福爾馬林致痛法、熱水致小鼠縮尾法，觀察TARS的鎮(zhèn)痛作用；采用小鼠棉球肉芽腫法、蛋清致小鼠足腫脹法，觀察其抗炎作用。結(jié)果 與對照組比較，高、中、低劑量TARS均可顯著降低福爾馬林致痛小鼠的疼痛強度，減少小鼠舔后足時間；顯著延長熱水所致的小鼠縮尾時間；顯著減少棉球肉芽組織增生模型中小鼠肉芽腫質(zhì)量；對蛋清引起的小鼠足腫脹發(fā)揮顯著抑制作用；且均呈劑量相關性。結(jié)論 TARS具有顯著的鎮(zhèn)痛抗炎作用。

Objective To study the analgesic and anti-inflammatory effects in vivo of the total alkaloids in Stephania kwangsiensis (TARS). Methods Mice were respectively ig with high, middle, and low doses of TARS. The analgesic effects of TARS were evaluated by the formaldehyde induced pain method and tail-immersion response induced by hot water in mice, and anti-inflammatory effects were observed by cotton ball granuloma, egg white induced paw swelling method in mice. Results TARS could significantly inhibit formaldehyde induced pain in mice, reduce the hind licking times, extend tail withdrawal time induced by hot water, obviously reduced the formation of granulomatous in mice; Inhibited egg white induced paw swelling. Conclusion TARS has significant analgesic and anti-inflammatory effect.

廣西高等學?？茖W研究項目（KY2015LX258）