目的 探討麝香保心丸聯(lián)合異山梨酯治療不穩(wěn)定型心絞痛（UAP）的療效及安全性。方法 選擇2014年6月-2016年6月榆陽區(qū)中醫(yī)醫(yī)院收治的80例UAP患者，隨機(jī)分為兩組，每組給40例，均予以基礎(chǔ)治療方案，對照組在基礎(chǔ)治療方案上加用異山梨酯治療，治療組加用麝香保心丸聯(lián)合異山梨酯治療，兩組均連續(xù)治療2周。比較兩組每日心絞痛發(fā)作次數(shù)、硝酸甘油用量以及心絞痛療效、心電圖（ECG）療效和藥物不良反應(yīng)。結(jié)果 治療前，兩組每日心絞痛發(fā)作次數(shù)和硝酸甘油用量差異無統(tǒng)計學(xué)意義；治療后，兩組每日心絞痛發(fā)作次數(shù)和硝酸甘油用量均明顯減少，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且治療組明顯少于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療組心絞痛療效總有效率為95.0%，明顯高于對照組的77.5%，差異有統(tǒng)計學(xué)意義（P<0.05）。治療組ECG療效總有效率為87.5%，明顯高于對照組的65.0%，差異有統(tǒng)計學(xué)意義（P<0.05）。治療組不良反應(yīng)發(fā)生率明顯低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 麝香保心丸聯(lián)合異山梨酯治療UAP能顯著提升療效，不良反應(yīng)少。

Objective To explore the efficacy and safety of Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of unstable angina pectoris. Methods 80 cases of UAP patients from Jun.2014 to Jun.2016 were given basic treatment plan, and 40 cases were randomly selected and treated with isosorbidedinitrate as the control group, and the other 40 cases were treated with Shexiang Baoxin Pill combined with isosorbidedinitrate. The incidence of angina pectoris and nitroglycerin dosage, angina pectoris curative effect, electrocardiogram (ECG) curative effect and adverse drug reactions were compared between the two groups. Results Before treatment, daily anginal attacks and nitroglycerin dosage of two groups had no significant difference; after treatment, daily anginal attacks and nitroglycerin dosage between two groups were obviously decreased, the differences of same group before and after treatment was statistically significant (P<0.05); and the treatment group was significantly less than the control group (P<0.05). The total effective rate of angina pectoris in the treatment group was higher than that in the control group, the difference was statistically significant (P<0.05). The total effective rate of ECG in the treatment group was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusions Shexiang Baoxin Pill combined with isosorbidedinitrate in the treatment of UAP can significantly improve the efficacy, and it's adverse reaction is less.