[關(guān)鍵詞]
[摘要]
目的 探討左卡尼汀聯(lián)合前列地爾治療糖尿病腎病的臨床療效及其安全性。方法 選擇2013年8月-2016年12月在內(nèi)蒙古醫(yī)科大學附屬醫(yī)院就診的糖尿病腎病患者102例,隨機分為兩組,對照組50例,患者接受前列地爾注射液治療;聯(lián)合組52例,在對照組的基礎(chǔ)上,聯(lián)合應(yīng)用左卡尼汀,兩組均持續(xù)治療1個月。分別檢測兩組患者治療前后的血糖水平以及腎功能相關(guān)指標;評價兩組患者治療后的臨床療效,記錄并分析兩組患者在治療期間不良反應(yīng)的發(fā)生情況。結(jié)果 經(jīng)治療,兩組患者的空腹血糖(FBG)、餐后2 h血糖(2 h BG)、24 h蛋白尿(24 h uPro)、血尿素氮(BUN)、血肌酐(Scr)以及尿微球蛋白(β2-MG)等均顯著降低,同組治療前后比較差異有統(tǒng)計學意義(P<0.05);且聯(lián)合組以上指標均低于對照組,差異有統(tǒng)計學意義(P<0.05)。經(jīng)治療,聯(lián)合組患者的治療總有效率為94.2%,顯著高于對照組的70.0%,差異有統(tǒng)計學意義(P<0.05)。治療期間,對照組發(fā)生不良反應(yīng)的總發(fā)生率為20.0%(10/50),聯(lián)合組為5.8%(3/52),其差異無統(tǒng)計學意義。結(jié)論 左卡尼汀聯(lián)合前列地爾用于治療糖尿病腎病臨床療效顯著,可有效控制血糖,改善腎功能,一定程度降低不良事件的發(fā)生率,值得臨床推廣應(yīng)用。
[Key word]
[Abstract]
Objective To explore the curative effect and safety of L-carnitine combined with alprostadil for patients with diabetic nephropathy. Methods 102 patients with diabetic nephropathy were enrolled in hospital of Inner Mongolia normal university from August 2013 to December 2016, of which patients divided into two groups randomly, control group (n=50) accepted alprostadil treatment, and combined group (n=52) adopted L-carnitine based on the patients in control group. The blood glucose and renal functions were detected respectively after treatment. And the curative effect was evaluated and compared between two groups; The adverse reactions were recorded and analyzed in the period of treatment. Results After treatment, the FBP, 2 h BG, 24 h uPro, BUN, Scr and β2-MG of patients in two groups were decreased significantly (P<0.05), and the change of combined group was higher than those control group significantly (P<0.05). After treatment, the total efficiency of combined group was higher than that patients in control group (P<0.05). The incidence of adverse reactions of control group in the period of treatment was 20.0% (10/50), and combined group was 5.8% (3/52), and which difference from two groups was no significance. Conclusions L-carnitine combined with alprostadil for patients with diabetic nephropathy deserved popularization in clinic, and which not only possessed remarkable curative effect, but also well controlled the blood glucose level, improved the renal function, decreased the incidence of adverse reactions certainly.
[中圖分類號]
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