目的 探討咪達(dá)唑侖聯(lián)合地西泮治療小兒驚厥持續(xù)狀態(tài)的療效及安全性。方法 將西安市兒童醫(yī)院自2014年1 月-2016年12月收治的小兒驚厥持續(xù)狀態(tài)患兒66例作為研究對(duì)象，根據(jù)入院時(shí)間隨機(jī)分為兩組，對(duì)照組32例患兒給予地西泮，研究組34例患兒在對(duì)照組基礎(chǔ)上給予咪達(dá)唑侖，觀察兩組患兒的治療效果和安全性。結(jié)果 研究組患者臨床有效率為94.12%，對(duì)照組為75.00%，組間比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。研究組藥物起效時(shí)間和驚厥控制時(shí)間均少于對(duì)照組，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。研究組患兒的呼吸道分泌物增多例數(shù)較對(duì)照組，但可耐受。結(jié)論 咪達(dá)唑侖聯(lián)合地西泮治療小兒驚厥持續(xù)狀態(tài)，起效快，安全有效，可在臨床范圍內(nèi)推廣使用。

Objective To investigate the therapeutic effect and safety of midazolam on the persistence of pediatric patients. Methods 66 cases of pediatric convulsions from January 2014 to December 2016 were enrolled in this study. According into the admission time, 34 cases children in the study group were treated with midazepam on the base of control group, the control group of 32 children with diazepam, two groups of children with therapeutic effect and safety were observed. Results The clinical effective rate was 94.12% in the study group and 75.00% in the control group. The difference between two groups was statistically significant (P<0.05). The time of onset and the time of convulsion were lower than those of the control group, the difference was statistically significant (P<0.05); the respiratory secretions increase of the study group was more than the control group, while who were tolerated. Conclusion Midazolam continuous intravenous infusion treatment of convulsion status, rapid onset, safe and effective, which can be used in the clinical scope.