雷公藤多苷是一種從植物雷公藤中提取出的有效組分，具有免疫抑制、抗炎等作用，臨床上多用于治療風濕性關(guān)節(jié)炎和腎病綜合征等。在雷公藤多苷眾多不良反應(yīng)中，其肝臟相關(guān)不良反應(yīng)尤為顯著。針對雷公藤多苷的肝毒性作用，總結(jié)近十年對雷公藤多苷肝毒性作用及機制的研究進展，并對其毒性物質(zhì)基礎(chǔ)進行了分析，對相應(yīng)的配伍減毒藥物以及其保護機制進行了總結(jié)分析，為雷公藤多苷的臨床合理使用及配伍減毒提供文獻和理論依據(jù)。

Tripterygium wilfordii glycoside is an effective component extracted from Tripterygium wilfordii Hook. F. It has an effect on immunosuppression and anti-inflammatory which is used to treatments of rheumatic arthritis and nephrotic syndrome on clinic. The liver adverse reactions have been particularly significant in Tripterygium wilfordii glycoside induced adverse reactions. The aim of this article is to summarize the research of hepatotoxicity mechanism of Tripterygium wilfordii glycoside in recent ten years, to analyze toxic material base, and to search for the attenuated drugs and mechanism. For the clinical application of Tripterygium wilfordii glycoside this article provides related literature and theoretical basis research.

公益性行業(yè)科研專項（201507004-002）；國家重大新藥創(chuàng)制專項（2015ZX09501004-002-004）；國家自然科學基金重大國際（地區(qū)）合作研究項目（No.81320108029）