熊果酸和齊墩果酸能對(duì)抗氧化型低密度脂蛋白（ox-LDL）、C-反應(yīng)蛋白、非酶糖基化終產(chǎn)物、高糖、H₂O₂、脂多糖對(duì)血管內(nèi)皮細(xì)胞的損傷，其血管藥理作用是多方面的。熊果酸和齊墩果酸能抑制血管平滑肌細(xì)胞增殖，也能對(duì)抗血清、ox-LDL、高糖、瘦蛋白誘導(dǎo)血管平滑肌細(xì)胞增殖，從而產(chǎn)生血管保護(hù)作用和改善血管功能；減輕糖尿病大鼠的血管損傷，減輕球囊導(dǎo)管損傷引起的血管狹窄，抑制靜脈橋移植后的血管壁炎癥反應(yīng)和血管外膜成纖維細(xì)胞增殖并防止血管狹窄，以及防止多種實(shí)驗(yàn)性動(dòng)脈粥樣硬化模型動(dòng)物的血管狹窄；對(duì)血管內(nèi)皮細(xì)胞有抑制增殖作用，也有對(duì)抗傷害因子抑制增殖或促進(jìn)增殖的雙向作用，因此對(duì)血管生成也有雙向調(diào)控作用，能抑制角膜、糖尿病動(dòng)物視網(wǎng)膜及腫瘤組織內(nèi)的血管新生；還有擴(kuò)張血管，降低血管阻力，對(duì)正常的和多種高血壓動(dòng)物有顯著的降壓作用。

Ursolic and oleanolic acids antagonize ox-LDL-, C-reactive protein-, non-enzymatic glycation end products-, hyper-glucose-, H₂O₂-, lipopolysaccharide-induced endothelial cell injury, and their vascular pharmacologic effects are in many ways. Ursolic and oleanolic acids can inhibit the proliferation of vascular smooth muscle cells, and antagonize serum-, ox-LDL-, hyper-glucose-, leptin-induced vascular smooth muscle cell proliferation, thus produce vascular protection and improve vascular function; Ursolic and oleanolic acids can relieve diabetic vascular complication in diabetic mellitus rats, and vascular stenosis induced by carotid balloon catheter injury, and suppress the proliferation of vascular adventitial fibroblasts and prevent vascular stenosis induced by various experimental atherosclerosis models; they can also inhibit the proliferation of vascular endothelial cells, and have a dual action to antagonize inhibiting or promoting proliferation induced by various injurious factions. Thus they have a dual role of regulation in angiogenesis, and suppress angiogenesis of cornea, diabetic retina, and tumor tissues, have effects of vascular relaxation and resistance decrease, and have hypotensive effects in normal and various hypertensive animals.