目的 探討萬(wàn)古霉素對(duì)老年心力衰竭合并肺部感染患者的炎癥因子及降鈣素原（PCT）水平的影響。方法 選取2015年1月-2016年12月南京軍區(qū)南京總醫(yī)院收治的心力衰竭合并肺部感染患者64例，隨機(jī)分為兩組，頭孢他啶組給予頭孢他啶，萬(wàn)古霉素組給予萬(wàn)古霉素，兩組均治療1周。評(píng)價(jià)兩組患者治療后的臨床效果，治療前后的腦利鈉肽（BNP）、炎癥因子及PCT水平的變化情況。結(jié)果 萬(wàn)古霉素組總有效率為84.37%，明顯高于頭孢他啶組的68.75%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后兩組BNP、腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-6（IL-6）、PCT均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且萬(wàn)古霉素組BNP、TNF-a、IL-6、PCT下降更為顯著，組間比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 萬(wàn)古霉素具有良好的抗菌作用，對(duì)心力衰竭合并肺部感染患者具有較好的臨床療效。

Objective To investigate the influence of vancomycin on inflammatory factor and PCT in elderly patients with heart failure combined with pulmonary infection. Methods 64 cases with heart failure combined with pulmonary infection from Jan. 2015 to Dec. 2016 in our hospital were chosen, who were randomly divided into two groups, who were taken with cephalosporin and vancomycin, the clinical efficacy of two groups after treatment were compared, the BNP, inflammatory factor and PCT level before and after treatment of two groups were compared. Results The total effective rate of vancomycin group was 84.37%, which was significantly higher than that of ceftazidime group, and the difference was statistically significant (P < 0.05). After treatment, the BNP, TNF-a, IL-6, PCT were significantly reduced in the two groups, and the difference was statistically significant (P < 0.05). And the BNP, TNF-a, IL-6, PCT of vancomycin group was decreased more significantly, the difference between the two groups was statistically significant (P < 0.05). Conclusion Vancomycin had great antibacterial action, which had great efficacy in treatment of heart failure combined with pulmonary infection patients.