目的 探討槐杞黃顆粒輔助治療兒童支氣管哮喘的臨床療效及對患兒免疫功能的影響。方法 將100例支氣管哮喘患兒隨機分為對照組與治療組各50例，均接受常規(guī)西醫(yī)治療，治療組同時輔以槐杞黃顆粒治療，2次/d，<3歲5.0 g/次， ≥ 3歲10 g/次。兩組均治療3個月。比較兩組治療前后白細胞介素-4（IL-4）、IL-5和γ干擾素（IFN-γ）水平，日間和夜間癥狀積分，臨床療效及隨訪3個月的復(fù)發(fā)率。結(jié)果 兩組治療后血清IL-4、IL-5水平均明顯降低，IFN-γ水平均明顯升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療組血清IL-4、IL-5水平明顯低于對照組，IFN-γ水平明顯高于對照組，組間差異有統(tǒng)計學(xué)意義（P<0.05）。兩組治療后日間和夜間癥狀積分均明顯降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；治療組明顯低于對照組，組間比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療組總有效率（96.0%）明顯優(yōu)于對照組（82.0%），差異有統(tǒng)計學(xué)意義（P<0.05）。治療組復(fù)發(fā)3例（6.0%），對照組復(fù)發(fā)12例（24.0%），治療組復(fù)發(fā)率明顯低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 槐杞黃顆粒輔助治療能有效改善支氣管哮喘患兒的免疫功能，增強療效，減少復(fù)發(fā)。

Objective To investigate Huaiqihuang particles in treatment of children with bron chialasthma and effect on immune function. Methods 100 cases of children with bronchial asthma were randomly divided into control group and treatment group, 50cases in each group, all were given routine western medicine treatment, and the treatment group combined with Huaiqihuang particles. The levels of interleukin-4 (IL-4), IL-5 and interferon gamma (IFN-γ), diurnal and nocturnal symptom scores before and after treatment and clinical efficacy and recurrence rate in followed up for 3 months in two groups were compared. Results After treatment, serum IL-4, IL-5 levels of the two groups were significantly decreased, IFN-γ levels were significantly increased in the same group before and after treatment, the difference was statistically significant (P < 0.05)., serum IL-4 and IL-5 levels of treatment group were significantly lower than the control group, IFN-γ levels were significantly higher than the control group, there was statistically significant difference between groups (P < 0.05). After treatment, daytime and nighttime symptom scores of two groups were significantly reduced than before treatment (P < 0.05). And the treatment group was significantly lower than the control group (P < 0.05). The total effective rate of the treatment group (96%) was significantly better than that of the control group (82%) (P < 0.05). The treatment group recurred in 3 cases (6%), and the control group relapsed in 12 cases (24%). The recurrence rate of the treatment group was lower than that of the control group (P < 0.05). Conclusion Huaiqihuang particles can effectively improve the immune function of patients with bron chialasthma, enhance efficacy and reduce recurrence.