目的 探討枸櫞酸咖啡因與氨茶堿治療早產(chǎn)兒原發(fā)性呼吸暫停的療效。方法 80例原發(fā)性呼吸暫停早產(chǎn)兒入院后被分為兩組，對(duì)照組（40例）給予氨茶堿治療，觀察組（40例）給予枸櫞酸咖啡因治療，依據(jù)治療后的療效、原發(fā)性呼吸暫停的發(fā)作次數(shù)和消失時(shí)間及治療期間不良反應(yīng)發(fā)生情況，評(píng)價(jià)枸櫞酸咖啡因與氨茶堿治療早產(chǎn)兒原發(fā)性呼吸暫停的療效。結(jié)果 觀察組有效率85.0%，對(duì)照組有效率75.0%，觀察組有效率明顯更高，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組呼吸暫停發(fā)生次數(shù)少于對(duì)照組，消失時(shí)間短于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療期間，觀察組患兒心動(dòng)過(guò)速、喂養(yǎng)不耐受、支氣管肺發(fā)育等不良反應(yīng)率均低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 與氨茶堿相比，枸櫞酸咖啡因?qū)υ绠a(chǎn)兒原發(fā)性呼吸暫停具有較好的治療效果，能快速降低呼吸暫停的發(fā)作頻率，消除臨床癥狀，具有較高的藥物安全性，是理想的用于治療原發(fā)性呼吸暫停的藥物。

Objective Discuss the clinical efficacy of caffeine citrate and aminophylline in treatment of primary apnea of prematurity. Methods 80 cases of primary apnea of prematurity were selected. They were divided into two groups randomly. The control group (40 cases) received aminophylline treatment and the observation group (40 cases) received caffeine citrate therapy. The efficacy of caffeine citrate and aminophylline in treatment of primary apnea of prematurity was evaluated by efficacy, primary apnea episodes and disappeared time, adverse reaction during treatment. Results The effective rate of observation group was 85%, the effective rate of control group was 75%. The observation group had higher efficiency (P < 0.05). The frequency of apnea of observation group was less than that of the control group. The disappearance time of observation group was shorter than that of the control group (P < 0.05). During the treatment, the tachycardia, feeding intolerance, bronchopulmonary dysplasia and other adverse reactions rate of observation group was lower than that of the control group (P < 0.05). Conclusion Compared with aminophylline, caffeine citrate had a good therapeutic effect of primary apnea of prematurity. It can reduce apnea frequency, eliminate clinical symptoms with high safety. It was an ideal drug for treatment of primary apnea.