齊墩果酸具有廣泛的藥理作用，包括抗炎、抗腫瘤、抗糖尿病、抗動脈粥樣硬化，保肝、抗骨質(zhì)疏松等。但是齊墩果酸口服的生物利用度低，通過被動擴(kuò)散被腸道吸收，齊墩果酸的分散體制劑能提高溶出度和生物利用度，且能濃集于肝臟，有利于治療肝部疾病。通過綜述齊墩果酸藥動學(xué)參數(shù)、體內(nèi)過程、齊墩果酸分散體及其前藥的藥動學(xué)特征，總結(jié)齊墩果酸的藥動學(xué)研究進(jìn)展，為合理用藥提供參考。

Oleanolic acid has a widespread pharmacologic effect, including anti-inflammation, antitumor, antidiabetes, anti-atherosclerosis, hepatoprotection, anti-osteoporosis, etc. Bioavailability of oleanolic acid by oral administration is low, and is absorbed by intestine through passive transport. Oleanolic acid dispersion preparation can increase its solubility and bioavailability, and concentrate on liver to help treat for hepatic disease. The pharmacokinetic parameters, process in body of oleanolic acid, and the pharmacokinetic feature of oleanolic acid dispersion and its prodrug are reviewed, and its research advance on pharmacokinetics is summarized, which provides a reference for rational utilization of oleanolic acid.