目的 通過成本-效果分析，評價兒童清咽解熱口服液治療小兒急性咽炎（肺胃實熱證）的經(jīng)濟學(xué)優(yōu)劣。方法 共納入急性咽炎（肺胃實熱證）患兒219例，以2：1：1的比例隨機分為試驗組、陽性藥對照組、安慰劑對照組，在以抗生素為基礎(chǔ)治療的條件下，分別服用兒童清咽解熱口服液、蒲地藍消炎口服液（陽性對照藥）、安慰劑，療程為5 d。選取咽痛療效、疾病療效和中醫(yī)癥候療效作為評價指標，進行成本-效果分析。結(jié)果 在咽痛療效方面，試驗組每多獲得1個單位的愈顯率，比安慰劑組僅需多花費0.62元，比陽性對照組少花費0.54元；在疾病療效方面，試驗組每多獲得1個單位的愈顯率，比安慰劑組多花費0.57元，比陽性對照組少花費0.54元；在中醫(yī)證候方面，試驗組每多獲得1個單位的愈顯率，比安慰劑組多花費0.58元，比陽性對照組少花費0.54元。結(jié)論 兒童清咽解熱口服液聯(lián)合抗生素治療小兒急性咽炎（肺胃實熱證），在咽痛癥狀療效、疾病療效和中醫(yī)癥候療效方面，較蒲地藍消炎口服液及單獨使用抗生素有較優(yōu)的經(jīng)濟性，與蒲地藍消炎口服液經(jīng)濟性相當，具有良好的臨床應(yīng)用前景。

Objective To evaluate cost-effectiveness of Qingyan Jiere Oral Liquid for the treatment of acute pharyngitis (lung-stomach excess-heat syndrome). Methods 219 patients were assigned to this study, and were randomly divided into treatment group, positive control group, and placebo control group in rate of 2:1:1. All patients took Azithromycin Granules as basic treatment, then took Qingyan Jiere Oral Liquid, Pudilan Xiaoyan Oral Liquid, or placebo, respectively. Treatment course lasted for 5 d. The curative effect of throat pain, efficacy of disease, and the traditional Chinese medicine (TCM) symptoms were observed by cost-effectiveness analysis. Results For analgesic efficacy, to get one more unit of markedly effective rate, patients in the treatment group need pay 0.62 yuan more than placebo group, and save 0.54 yuan when comparing with positive control group. For disease curative efficacy, to get one more percentage point of markedly effective rate, patients in the treatment group need pay extra 0.57 yuan than placebo group, and save 0.54 yuan than positive control group. For TCM syndrome efficacy, to get one more percentage point of markedly effective rate, patients in the treatment group need pay extra 0.58 yuan than placebo group, and save 0.54 yuan than positive control group. Conclusion Qingyan Jiere Oral Liquid, with cost-effectiveness advantage on relieving sore throat, curing disease and improving TCM symptoms, is a good choice for treating acute pharyngitis (lung-stomach excess-heat syndrome).