目的 評(píng)價(jià)小兒肺熱咳喘口服液聯(lián)合阿奇霉素治療支原體肺炎的有效性和安全性。方法 中國(guó)知網(wǎng)（CNKI）、萬(wàn)方數(shù)據(jù)庫(kù)（WF）、維普數(shù)據(jù)庫(kù)（VIP）、中國(guó)生物醫(yī)學(xué)全文數(shù)據(jù)庫(kù)（CBM）、PubMed、EMbase和Cochrane Library等數(shù)據(jù)庫(kù)，納入隨機(jī)對(duì)照試驗(yàn)（RCT），提取有效數(shù)據(jù)進(jìn)行Meta-分析。結(jié)果 共納入12個(gè)RCT，1 234病例，試驗(yàn)組619例，對(duì)照組615例。Meta結(jié)果顯示，小兒肺熱咳喘口服液聯(lián)合阿奇霉素在總有效率[RR=1.18，95% CI（1.13，1.23），P<0.000 01]，退熱時(shí)間[MD=-0.85，95% CI（-1.19，-0.51），P<0.000 01]、咳嗽消失時(shí)間[MD=-2.54，95% CI（-3.38，-1.69），P<0.000 01]、肺部啰音消失時(shí)間[MD=-1.53，95% CI（-2.24，-0.81），P<0.000 1]、咳痰消失時(shí)間[MD=-1.63，95% CI（-1.96，-1.30），P<0.000 01]及減少住院天數(shù)方面均優(yōu)于單用阿奇霉素，差異均有統(tǒng)計(jì)學(xué)意義；兩組不良反應(yīng)發(fā)生率（RR=0.70，95% CI（0.26，1.87），P=0.48），差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 小兒肺熱咳喘口服液聯(lián)合阿奇霉素治療兒童支原體肺炎的療效優(yōu)于單用阿奇霉素，且聯(lián)合應(yīng)用并未增加不良反應(yīng)發(fā)生率。

Objective To evaluate the efficacy and safety of Xiao'er Feire Kechuan Oral Liquid combined with azithromycin in the treatment of pediatric mycoplasma mycoplasma pneumonia. Methods The databases of PubMed, EMbase, Cochrane Library, CKNI, WF, VIP, and CBM were systematically searched to collect the randomized controlled trials (RCTs), the valid data from which were entered Meta-analysis. Results A total of 12 RCTs were brought in, including 1234 cases, of which 619 cases were in the treatment group and 615 were in the control group. Meta-analysis showed that clinical efficacy of treatment group of Xiao'er Feire Kechuan Oral Liquid combined with azithromycin was superior than those in single azithromycin group at the total effective rate of[RR=1.18, 95% CI (1.13, 1.23), P<0.000 01], fever subsidence time of[MD=-0.85, 95% CI (-1.19, -0.51), P<0.000 01], cough disappearance time of[MD=-2.54, 95% CI (-3.38, -1.69), P<0.000 01], lung rales disappearance time of[MD=-1.53, 95% CI (-2.24, -0.81), P<0.000 01], expectoration disappearance time[MD=-1.63, 95% CI (-1.96, -1.30), P<0.000 01], and reduction of hospital stay. The differences between groups were statistically significant. There was no statistical difference in the adverse effects[RR=0.70, 95% CI (0.26, 1.87), P=0.48] between two groups. Conclusion Xiao'er Feire Kechuan Oral Liquid combined with azithromycin might have a better clinical efficacy on the pediatric mycoplasma mycoplasma pneumonia than using azithromycin singly, and the combined application of medicine did not increase the incidence of adverse reactions