目的 探討孟魯斯特聯(lián)合布地奈德治療咳嗽變異性哮喘（CVA）患兒的臨床療效及對(duì)肺功能的影響。方法 選取2014年3月-2017年3月渭南市第一醫(yī)院收治的CVA患兒280例，按照治療方式分為對(duì)照組和觀察組，各140例。對(duì)照組在常規(guī)治療的基礎(chǔ)上給予患兒布地奈德治療，觀察組在對(duì)照組的基礎(chǔ)上給予孟魯斯特治療，兩組均治療60 d。比較兩組的臨床療效，治療前后肺功能指標(biāo)呼氣流量峰值（PEF）、1s用力呼吸容積（FEV1）及一秒率（FEV1/FVC），比較兩組不良反應(yīng)的發(fā)生情況。結(jié)果 治療后，觀察組臨床療效的總有效率是94.29%，顯著高于對(duì)照組的77.14%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組患兒治療前的肺功能指標(biāo)比較無明顯差異，兩組治療后以上檢測(cè)指標(biāo)較治療前均顯著提高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后，觀察組PEF、FEV1、FEV1/FVC水平均顯著高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組患兒在治療期間均無嚴(yán)重不良反應(yīng)的發(fā)生，不良反應(yīng)發(fā)生情況無顯著差異。結(jié)論 孟魯斯特聯(lián)合布地奈德治療咳嗽變異性哮喘比單用布地奈德治療的臨床效果好，可有效改善患兒的肺功能，值得臨床推廣。

Objective To explore the clinical efficacy of budesonide combined with montelukast in the treatment of children with cough variant asthma and its effect on lung function. Methods Selected 280 cases of children with cough variant asthmain our hospital from March 2014 to March 2017. All patients were divided into control group and observation group by treatment, 140 cases in each group. The control group was treated with budesonide on the basis of conventional treatment, the observation group was treated with montelukast on the basis of control group. The total effective rate was compared between the two groups. The levels of peak expiratory flow (PEF), orced expiratory volume in 1 second (FEV1), forced expired volume inone second to forced vital capacityratio (FEV1/FVC) were compared between the two groups before and after treatment. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05) after treatment. There were no significant differences in lung function between the two groups before treatment. The levels of PEF, FEV1, FEV1/FVC in the two groups were significantly higher than those before treatment (P<0.05). The levels of PEF, FEV1 and FEV1/FVC in the observation group were significantly higher than those in the control group (P<0.05) after treatment. There was no significant adverse reaction between the two groups during the treatment, and there was no significant difference in the incidence of adverse reactions. Conclusions Budesonide combined with montelukast treatment of cough variant asthma than budesonide treatment of clinical effect is good, can effectively improve the lung function of children, worthy of clinical promotion.