慢性非可控性炎癥在代謝性疾病如糖尿病、非酒精性脂肪性肝病（NAFLD）和動(dòng)脈粥樣硬化的發(fā)生和發(fā)展過程中發(fā)揮關(guān)鍵作用。天然產(chǎn)物小檗堿對(duì)代謝性疾病有良好的改善作用并對(duì)其伴隨的慢性炎癥有明顯的抑制作用。研究顯示小檗堿主要通過調(diào)控AMP依賴的蛋白激酶（AMPK）、核轉(zhuǎn)錄因子-κB（NF-κB）和腸道菌群來發(fā)揮抗炎活性。對(duì)小檗堿抗炎作用的深入研究將為其應(yīng)用于臨床治療代謝性疾病提供進(jìn)一步科學(xué)依據(jù)。

Chronic noncontrollable inflammation is crucial for the onset and development of metabolic diseases such as diabetes mellitus, nonalcoholic fatty liver disease (NAFLD), and atherosclerosis. The natural product berberine has favorable improving activities on metabolic diseases and has significant inhibitory activities on chronic inflammation accompanied. The studies showed that the anti-inflammatory activity of berberine was mainly associated with the modulation of AMP-activated protein kinase (AMPK), nuclear factor-κB (NF-κB), as well as the gut microbiota. The in-depth investigation of the anti-inflammatory activity of berberine will provide further scientific evidences for its clinical application to treat metabolic diseases.

中國(guó)醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與健康科技創(chuàng)新工程（No.2016-I2M-1-011）