腫瘤多藥耐藥是腫瘤治療過程中一個亟待解決的難題，其表現(xiàn)為腫瘤細胞對單一或多種化療藥物同時出現(xiàn)耐藥性，從而導(dǎo)致治療失敗，與藥物的化學(xué)結(jié)構(gòu)和作用機制無關(guān)。將化療藥物與腫瘤多藥耐藥逆轉(zhuǎn)劑聯(lián)合應(yīng)用是目前公認的治療方案之一。黃酮類化合物由于其低毒、高效，具有多種藥理作用等優(yōu)點而受到廣泛的關(guān)注。在腫瘤治療期間，黃酮類化合物能通過抑制ABC轉(zhuǎn)運體、誘導(dǎo)凋亡、調(diào)節(jié)氧化應(yīng)激等作用逆轉(zhuǎn)腫瘤多藥耐藥。歸納總結(jié)了黃酮類化合物逆轉(zhuǎn)腫瘤多藥耐藥的主要機制、應(yīng)用及其納米劑型改造的進展，為進一步的臨床研究提供參考。

Trumor multidrug resistance (MDR) is a problem that needs to be solved in the course of tumor treatment. MDR is characterized by the simultaneous emergence of resistance to single or multiple chemotherapeutic drugs in tumor cells resulting in treatment failure, regardless of the chemical structure and mechanism of the drug. Combining chemotherapeutic agents with MDR reversal agents is currently recognized as one of the treatment options. Flavonoids have received extensive attention because of their low toxicity, high efficiency, and their many pharmacological effects. During the treatment of tumors, flavonoids can reverse MDR by inhibiting ABC transporter, inducing apoptosis and regulating oxidative stress. This article summarizes the main mechanisms of flavonoids on reversal MDR and the progress of the modification of nano-formulations, in order to provide reference for further clinical research.

國家自然科學(xué)基金資助項目（81473280）；遼寧省自然科學(xué)基金資助項目（20170540293）