在過去的數(shù)十年內(nèi)對(duì)p53基因及其產(chǎn)物的研究取得了重大進(jìn)展，而腫瘤的多藥耐藥已經(jīng)成為現(xiàn)今腫瘤治療的重大障礙?？紤]到p53基因作為抑癌基因的重要意義，整理歸納了p53及其產(chǎn)物在抑癌方面的主要機(jī)制，腫瘤多藥耐藥基因之間的相互作用關(guān)系以及在神經(jīng)系統(tǒng)中p53基因突變的反常保護(hù)機(jī)制，以期為逆轉(zhuǎn)抗腫瘤藥的多藥耐藥提供新思路。

significant progress has been made in the study of p53 gene and its products in the past decades, the multidrug resistance of tumor has become a major obstacle in the treatment of tumor. Considering the significance of p53 gene a tumor suppressor genes, in this article, we sums up the main mechanism of the interaction between tumor multi-resistant genes and p53 with its products, accompanied with p53 gene mutation in the nervous system of abnormal protection mechanism in order to provide new thought of reversing the tumor MDR.

國家自然科學(xué)基金資助項(xiàng)目（81473280）