目的 研究紅花注射液聯(lián)合重組組織型纖溶酶原激活劑（rt-PA）對急性腦梗死的療效、血液流變學(xué)和血脂的影響。方法 選擇2014年1月—2017年6月新疆建設(shè)兵團(tuán)額敏第九師醫(yī)院的90例急性腦梗死患者，隨機(jī)分為兩組。對照組給予rt-PA 0.9 mg/kg進(jìn)行溶栓治療，觀察組在對照組給藥基礎(chǔ)上聯(lián)合靜脈滴注紅花注射液40 mL，比較兩組治療前后的血小板聚集率、血黏稠度等血液流變學(xué)參數(shù)以及總膽固醇（TC）、低密度脂蛋白（LDL）、三酰甘油（TG）等血脂指標(biāo)，ADL量表評分以及NIHSS量表評分。結(jié)果 觀察組的有效率為93.34%，明顯高于對照組的73.34%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；治療后兩組的血小板聚集率和血黏稠度均明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05），且觀察組明顯低于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組治療后的TC、LDL、TG均明顯改善，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05），且觀察組明顯優(yōu)于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組治療后的ADL量表評分明顯升高（P<0.05），NIHSS量表評分明顯降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05），且觀察組更為明顯（P<0.05）。結(jié)論 紅花注射液聯(lián)合rt-PA對急性腦梗死的治療效果明顯優(yōu)于單純使用rt-PA，可以改善患者的血液流變學(xué)，降低血脂，從而有效改善患者的日常生活能力和神經(jīng)功能。

Objective To investigate the influence of efficacy, hemorheology, blood lipid of Safflower Injection combeind with recombinant tissue plasminogen activator on patients with acute cerebral infarction. Methods From Jan. 2014 to June 2017, 90 cases with acute cerebral infarction in our hospital were chosen and randomly divided into two groups. The control group were given rt-PA 0.9 mg/kg on thrombolytic therapy, the observation group were given Safflower Injection (40 mL) combined with recombinant tissue plasminogen activator, the blood rheological parameters of platelet aggregation, blood viscosity and blood lipid (TC, LDL, TG) were compared, the ADL scale score and NIHSS scale score of two groups were compared. Results The efficacy of observation group was higher than control group (P<0.05), the platelet aggregation and blood viscosity of two groups after treatment were decreased (P<0.05), while the observation group was decreased obviously than control group (P<0.05); the ADL scale score of two groups after treatment were higher (P<0.05), NIHSS scale score were all decreased (P<0.05), while the observation group was decreased obviously (P<0.05). Conclusion The Safflower Injection combined with recombinant tissue plasminogen activator had better efficacy on acute cerebral infarction than rt-PA, which could improve the hemorheology, decrease the blood lipid, and improve the daily life and neurological function.