目的 探討不同劑量米力農(nóng)對(duì)新生兒肺動(dòng)脈高壓（PPHN）的療效及肝腎功能的影響。方法 將2013年5月—2017年6月收治的96例肺動(dòng)脈高壓新生兒均分為A、B、C 3組，在常規(guī)治療的基礎(chǔ)上應(yīng)用米力農(nóng)注射液治療，3組維持劑量分別為0.25、0.50、0.75 μg/(kg·min)。比較3組的血?dú)庵笜?biāo)、療效和肝腎功能指標(biāo)。結(jié)果 3組治療后的肺動(dòng)脈血氧飽和度（SpO₂）、氧分壓（PaO₂）高于治療前且二氧化碳分壓（PaCO₂）、肺動(dòng)脈收縮壓（PASP）低于治療前，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且C組的改善幅度大于A、B組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；A組的改善幅度小于B組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。經(jīng)治療，C組的總有效率高于A、B兩組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；A組總有效率低于B組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。3組治療后的丙氨酸氨基轉(zhuǎn)移酶（ALT）、天門(mén)冬氨酸氨基轉(zhuǎn)移酶（AST）、尿素氮（BUN）和血肌酐（Scr）與治療前差異無(wú)統(tǒng)計(jì)學(xué)意義，且治療前后組間差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 在常規(guī)治療的基礎(chǔ)上應(yīng)用米力農(nóng)治療PPHN可明顯改善血?dú)庵笜?biāo)，療效顯著，無(wú)肝腎功能損傷及其他不良反應(yīng)，最佳維持劑量為0.75 μg/(kg·min)。但有必要擴(kuò)大樣本量以對(duì)合適的劑量做進(jìn)一步系統(tǒng)研究。

Objective To discuss the curative effect of different doses of milrinone in treatment with pulmonary hypertension in newborns (PPHN) and its effect on liver and kidney function. Methods A total of 96 pulmonary hypertension newborns treated in our hospital from May 2013 to June 2017 were divided into group A, B and C on the basis of routine therapy. The maintenance dose of milrinone for three groups were 0.25, 0.50, and 0.75 μg/(kg·min), respectively. The blood gas index, curative effect and liver and kidney function indexes of the three groups were compared. Results After treatment, SpO₂, PaO₂ and PaCO₂ and PASP of three groups were lower than those before (P<0.05), and the improvement of group C was greater than that of group A and group B (P<0.05), the improvement of group A was less than that of group B (P<0.05). After treatment, the total effective difference between the three groups was statistically significant (P<0.05), and the total effective rate of group C was higher than that of group A and B (P<0.05), and the total effective rate of group A was lower than that of group B (P<0.05). There was no statistically significant difference in ALT, AST, BUN and Scr after treatment among three groups, and there was no significant difference of three groups before and after treatment. Conclusion On the basis of conventional treatment, milrinone in treatment with PPHN can obviously improve the blood gas index and the efficacy is remarkable, it shows no liver and kidney function injury and other adverse reactions. And the optimal maintenance dose is 0.75 μg/(kg·min). However, it is necessary to enlarge the sample size to study the appropriate dosagefurtherly.